This paper presents a computational study of the effects of three parameters on the resulting thoracic injury criteria in side impacts. The parameters evaluated are a) door velocity-time (V-t) profile, b) door interior padding modulus, and c) initial door-tooccupant offset. Regardless of pad modulus, initial offset, or the criterion used to assess injury, higher peak door velocity is shown to correspond with more severe injury. Injury outcome is not, however, found to be sensitive to the door velocity at the time of first occupant contact. A larger initial offset generally is found to result in lower injury, even when the larger offset results in a higher door velocity at occupant contact, because the increased offset results in contact later in the door V-t profile - closer to the point at which the door velocity begins to decrease. Cases of contradictory injury criteria trends are identified, particularly in response to changes in the pad modulus. Maximum chest deflection and maximum viscous criterion gradually decrease as the padding modulus increases. TTI, however, increases with some increases in pad modulus. Complex interactions among the three parameters are observed, and their interpretation is shown to depend on the specific injury criterion analyzed.