Experimental strain-gauge and theoretical stress analysis methods are used to evaluate the mechanical behavior of the femur as a structural element under loading. It is shown that when the cortical bone material is assumed to behave linear elastic, homogeneous and transversely isotropic, excellent agreement between experimental results and theoretical predictions is obtained. Also that the bone shaft can with reasonable approximation be represented by an axisymmetric model, even when intramedullary hip joint prostheses are present. The implications of these results for the analysis of intramedullary bone-prosthesis structures are discussed.