Development and validation of a musculoskeletal model of the fully articulated thoracolumbar spine and rib cage

Bruno, Alexander G.; Bouxsein, Mary L.; Anderson, Dennis E.

Affiliations

¹Harvard-MIT Health Sciences and Technology Program, Massachusetts Institute of Technology, Cambridge, MA 02139

²Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, 330 Brookline Ave., RN121, Boston, MA 02215

³Department of Orthopedic Surgery, Harvard Medical School, Boston, MA 02115

Abstract

We developed and validated a fully articulated model of the thoracolumbar spine in opensim that includes the individual vertebrae, ribs, and sternum. To ensure trunk muscles in the model accurately represent muscles in vivo, we used a novel approach to adjust muscle cross-sectional area (CSA) and position using computed tomography (CT) scans of the trunk sampled from a community-based cohort. Model predictions of vertebral compressive loading and trunk muscle tension were highly correlated to previous in vivo measures of intradiscal pressure (IDP), vertebral loading from telemeterized implants and trunk muscle myoelectric activity recorded by electromyography (EMG).

Links

DOI: 10.1115/1.4030408

PubMed: 25901907

WoS: 000357336300003

History

Received: 2014-10-23

Revised: 2015-04-06

Online: 2915-06-09

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Year	Entry
2022	Low L, Newell N, Masouros S. A multibody model of the spine for injury prediction in high-rate vertical loading. In: Proceedings of the 2022 International IRCOBI Conference on the Biomechanics of Injury. September 14-16, 2022; Porto, Portugal.452-460.
2023	Akhavanfar M, Uchida TK, Graham RB. Evaluation of spinal force normalization techniques. J Biomech. January 2023;147:111441.
2023	Yan C, Lynch AC, Alemi MM, Banks JJ, Bouxsein ML, Anderson DE. Validity of evaluating spinal kinetics without participant-specific kinematics. J Biomech. December 2023;161:111821.
2020	Burkhart K, Allaire B, Anderson DE, Lee D, Keaveny TM, Bouxsein ML. Effects of long‐duration spaceflight on vertebral strength and risk of spine fracture. J Bone Miner Res. February 2020;35(2):269-276.
2021	Mokhtarzadeh H, Anderson DE, Allaire BT, Bouxsein ML. Patterns of load‐to‐strength ratios along the spine in a population‐based cohort to evaluate the contribution of spinal loading to vertebral fractures. J Bone Miner Res. April 2021;36(4):704-711.
2019	Beaucage-Gauvreau E. Brace for it: Assessing Lumbar Spinal Loads for a Braced Arm-to-Thigh Lifting and Bending Technique Using a Musculoskeletal Modelling Approach [PhD thesis]. University of Adelaide; June 2019.
2019	Huang S. Developing a Method for Estimating Subject-Specific Trunk Muscle Morphometry [Master's thesis]. Boston University; 2019.
2020	Cox CA. Computational Modeling of the Lumbar Spine: Active Musculature and Intra‐abdominal Pressure in Compressive Loading [PhD thesis]. Duke University; 2020.
2017	Actis J. Modeling Low Back Biomechanics in People With a Transtibial Amputation [Master's thesis]. Colorado School of Mines; 2017.
2017	Honegger JD. Development of a Multiscale Model of the Lumbar Spin: Application for Persons With a Lower-Limb Amputation [Master's thesis]. Colorado School of Mines; 2017.
2019	Sturdy J. Development of a Musculoskeletal Model for Load Carriage [Master's thesis]. Colorado School of Mines; 2019.
2020	Honegger JD. Multiscale Modeling of the Lumbar Spine to Investigate Tissue-Level Load Transfer During Activities of Daily Living [PhD thesis]. Colorado School of Mines; 2020.
2015	Bruno AG. Investigation of Spine Loading to Understand Vertebral Fractures [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2015.
2016	Kendrick DP. The Gravity Loading Countermeasure Skinsuit: A Passive Countermeasure Garment for Preventing Musculoskeletal Deconditioning During Long-Duration Spaceflight [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2016.
2019	Burkhart KA. Understanding Vertebral Fracture Risk in Astronauts [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2019.
2017	Raabe ME. The Effect of Core Stability on Running Mechanics in Novice Runners [PhD thesis]. The Ohio State University; 2017.
2019	Ghezelbash F. Subject-Specific Computational Musculoskeletal Modeling of Human Trunk in Lifting: Role of Age, Sex, Body Weight and Body Height [PhD thesis]. École polytechnique de Montréal; December 2019.
2021	Vega M. Development and Applications of Neuromusculoskeletal Modeling Software for Personalized Treatment Design [PhD thesis]. Houston, TX: Rice University; 2021.
2022	Eriksen Daehlin T. The Role of the Ankle Plantar Flexors, Extrinsic Foot Muscles, and Intrinsic Foot Muscles in Performing Propulsive Tasks [PhD thesis]. Edmonton, AB: University of Alberta; 2022.
2020	Pai S A. Investigation of Thoracic Spine and Muscle Morphology With Open Upright MRI [Master's thesis]. Vancouver, BC: University of British Columbia; December 2020.
2021	Malakoutian M. Biomechanical Properties of Paraspinal Muscles and Their Influence on Spinal Loading: An Experimental and Computational Investigation [PhD thesis]. Vancouver, BC: University of British Columbia; May 2021.
2021	Shaikh NS. Upright Magnetic Resonance Imaging of Lumbopelvic Musculature [PhD thesis]. Vancouver, BC: University of British Columbia; July 2021.
2022	Nolasco LA. Biomechanical Adaptations to Lower Limb Amputation During Functional Mobility Tasks [PhD thesis]. University of Michigan; 2022.