Technical note:​ recommendations for a standard procedure to assess cortical bone at the tissue-level in vivo using impact microindentation

Diez-Perez, A.; Bouxsein, M.L.; Eriksen, E.F.; Khosla, S.; Nyman, J.S.; Papapoulos, S.; Tang, S.Y.

Affiliations

¹Department of Internal Medicine, Hospital del Mar-IMIM, Autonomous University of Barcelona and RETICEF, Instituto Carlos III, Spain

²Center for Advanced Orthopedic Studies, Beth Isreal Deaconess Medical Center and Department of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA

³Dept. of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway

⁴Division of Endocrinology and Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA

⁵Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA

⁶Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands

⁷Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO, USA

Abstract and keywords

Impact microindentation is a novel method for measuring the resistance of to indentation in patients. Clinical use of a handheld impact microindentation technique is expanding, highlighting the need to standardize the measurement technique. Here, we describe a detailed standard operation procedure to improve the consistency and comparability of the measurements across centers.

Keywords: Bone microindentation; Impact microindentation; Bone tissue characteristics

Links

DOI: 10.1016/j.bonr.2016.07.004

PubMed: 27975078

PubMedCentral: PMC5152622

History

Received: 2016-04-11

Revised: 2016-06-27

Accepted: 2016-07-24

Online: 2016-07-26

Cited Works (6)

Year	Entry
1998	Rho J-Y, Kuhn-Spearing L, Zioupos P. Mechanical properties and the hierarchical structure of bone. Med Eng Phys. 1998;20(2):92-102.
2010	Diez‐Perez A, Güerri R, Nogues X, Cáceres E, Peña MJ, Mellibovsky L, Randall C, Bridges D, Weaver JC, Proctor A, Brimer D, Koester KJ, Ritchie RO, Hansma PK. Microindentation for in vivo measurement of bone tissue mechanical properties in humans. J Bone Miner Res. 2010;25(8):1877-1885.
2014	Zimmermann EA, Gludovatz B, Schaible E, Busse B, Ritchie RO. Fracture resistance of human cortical bone across multiple length-scales at physiological strain rates. Biomaterials. July 2014;35(21):5472-5481.
2008	Hansen U, Zioupos P, Simpson R, Currey JD, Hynd D. The effect of strain rate on the mechanical properties of human cortical bone. J Biomech Eng. February 2008;130(1):011011.
2010	Zebaze RMD, Ghasem-Zadeh A, Bohte A, Iuliano-Burns S, Mirams M, Price RI, Mackie EJ, Seeman E. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet. May 15, 2010;375(9727):1729-1736.
2014	Farr JN, Drake MT, Amin S, Melton LJ III, McCready LK, Khosla S. In vivo assessment of bone quality in postmenopausal women with type 2 diabetes. J Bone Miner Res. April 2014;29(4):787-795.

Cited By (15)

Year	Entry
2020	Blom-Høgestøl IK, Mala T, Kristinsson JA, Brunborg C, Gulseth HL, Eriksen EF. Changes in bone quality after Roux-en-Y gastric bypass: a prospective cohort study in subjects with and without type 2 diabetes. Bone. January 2020;130:115069.
2020	Rokidi S, Bravenboer N, Gamsjaeger S, Misof B, Blouin S, Chavassieux P, Klaushofer K, Paschalis E, Papapoulos S, Appelman-Dijkstra N. Impact microindentation assesses subperiosteal bone material properties in humans. Bone. February 2020;131:115110.
2020	Holloway-Kew KL, Rufus-Membere P, Anderson KB, Betson A, Gaston J, Kotowicz MA, Diez-Perez A, Hyde NK, Pasco JA. Bone material strength index is associated with prior fracture in men with and without moderate chronic kidney disease. Bone. April 2020;133:115241.
2020	Rokidi S, Bravenboer N, Gamsjaeger S, Chavassieux P, Zwerina J, Paschalis E, Papapoulos S, Appelman-Dijkstra N. Impact microindentation measurements correlate with cortical bone material properties measured by Fourier transform infrared imaging in humans. Bone. August 2020;137:115437.
2021	Holloway-Kew KL, Betson A, Rufus-Membere PG, Gaston J, Diez-Perez A, Kotowicz MA, Pasco JA. Impact microindentation in men with impaired fasting glucose and type 2 diabetes. Bone. January 2021;142:115685.
2022	Holloway-Kew KL, Rufus-Membere P, Anderson KB, Tembo MC, Sui SX, Hyde NK, Diez-Perez A, Kotowicz MA, Pasco JA. Associations between parameters of peripheral quantitative computed tomography and bone material strength index. Bone. February 2022;155:116268.
2022	Ovejero D, Garcia-Giralt N, Martínez-Gil N, Rabionet R, Balcells S, Grinberg D, Pérez-Jurado LA, Nogués X, Etxebarria-Forondad I. Clinical description and genetic analysis of a novel familial skeletal dysplasia characterized by high bone mass and lucent bone lesions. Bone. August 2022;161:116450.
2022	Willett TL, Voziyan P, Nyman JS. Causative or associative: a critical review of the role of advanced glycation end-products in bone fragility. Bone. October 2022;163:116485.
2018	Unal M, Creecy A, Nyman JS. The role of matrix composition in the mechanical behavior of bone. Curr Osteoporos Rep. June 2018;16(3):205-215.
2022	Ahmed R, Uppuganti S, Derasari S, Meyer J, Pennings JS, Elefteriou F, Nyman JS. Identifying bone matrix impairments in a mouse model of neurofibromatosis type 1 (NF1) by clinically translatable techniques. J Bone Miner Res. August 2022;37(8):1603-1621.
2020	Ballesta S, Güerri-Fernández RC, Chillarón JJ, Güell A, Herrera S, Torres E, Ascoeta NG, Le-Roux JAF, Díez A. The use of microindentation for the study of bone properties in type 1 diabetes mellitus patients. Osteoporos Int. January 2020;31(1):175-180.
2020	Starr JR, Tabacco G, Majeed R, Omeragic B, Bandeira L, Rubin MR. PTH and bone material strength in hypoparathyroidism as measured by impact microindentation. Osteoporos Int. February 2020;31(2):327-333.
2020	Schoeb M, Malgo F, Peeters JJM, Winter EM, Papapoulos SE, Appelman-Dijkstra NM. Treatments of osteoporosis increase bone material strength index in patients with low bone mass. Osteoporos Int. September 2020;31(9):1683-1690.
2022	Peruzzi CRP. Nanoscale Deformation Mechanisms and Yield Prediction of Lamellar Bone [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2022.
2018	Creecy A. Age- and Diabetes-Related Changes in the Matrix and Fracture Resistance of Bone [PhD thesis]. Nashville, TN: Vanderbilt University; August 10, 2018.