Perspectives:​ mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption

Rodan, Gideon A.

Affiliations

¹Department of Bone Biology and Osteoporosis Research, Merck, Sharp and Dohme Research Laboratmxies, West Point, PA 19486

Links

DOI: 10.1002/jbmr.5650060602

PubMed: 1887815

WoS: A1991GN78700001

Cited Works (15)

Year	Entry
1988	Pead MJ, Skerry TM, Lanyon LE. Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading. J Bone Miner Res. December 1988;3(6):647-656.
1990	Mosekilde L. Consequences of the remodelling process for vertebral trabecular bone structure: a scanning electron microscopy study (uncoupling of unloaded structures). Bone Miner. July 1990;10(1):13-35.
1989	Pead MJ, Lanyon LE. Indomethacin modulation of load-related stimulation of new bone formation in vivo. Calcif Tiss Int. January 1989;45(1):34-40.
1989	Weinreb M, Rodan GA, Thompson DD. Osteopenia in the immobilized rat hind limb is associated with increased bone resorption and decreased bone formation. Bone. 1989;10(3):187-194.
1990	Eriksen EF, Hodgson SF, Eastell R, Cedel SL, O'Fallon WM, Riggs BL. Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels. J Bone Miner Res. April 1990;5(4):311-319.
1982	Benya PD, Shaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell. August 1982;30(1):215-224.
1984	Parfitt AM. The cellular basis of bone remodeling: the quantum concept reexamined in light of recent advances in the cell biology of bone. Calcif Tiss Int. March 1984;36(suppl 1):S37-S45.
1990	Murray DW, Rushton N. The effect of strain on bone cell prostaglandin E₂ release: a new experimental method. Calcif Tiss Int. July 1990;47(1):35-39.
1990	Li XJ, Jee WSS, Chow S-Y, Woodbury DM. Adaptation of cancellous bone to aging and immobilization in the rat: a single photon absorptiometry and histomorphometry study. Anat Rec. May 1990;227B(1):12-24.
1988	Frost HM. Vital biomechanics: proposed general concepts for skeletal adaptations to mechanical usage. Calcif Tiss Int. May 1988;42(3):145-156.
1984	Binderman I, Shimshoni Z, Somjen D. Biochemical pathways involved in the translation of physical stimulus into biological message. Calcif Tiss Int. March 1984;36(1):S82-S85.
1984	Yeh C-K, Rodan GA. Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons. Calcif Tiss Int. March 1984;36(1):S67-S71.
1981	Doty SB. Morphological evidence of gap junctions between bone cells. Calcif Tiss Int. 1981;33(5):509-512.
1986	Globus RK, Bikle DD, Morey-Holton E. The temporal response of bone to unloading. Endocrinology. February 1986;118(2):733-742.
1980	Somjen D, Binderman I, Berger E, Harell A. Bone remodelling induced by physical stress is prostaglandin E₂ mediated. Biochim Biophys Acta. January 3, 1980;627(1):91-100.

Cited By (25)

Year	Entry
2001	Jee WSS. Integrated bone tissue physiology: anatomy and physiology. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:1-1–1-68.
2020	Sims NA, Martin TJ. Osteoclasts provide coupling signals to osteoblast lineage cells through multiple mechanisms. Annu Rev Physiol. February 10, 2020;82:507-529.
1996	Mullender MG, van der Meer DD, Huiskes R, Lips P. Osteocyte density changes in aging and osteoporosis. Bone. February 1996;18(2):109-113.
2005	Ruimerman R, Hilbers P, van Rietbergen B, Huiskes R. A theoretical framework for strain-related trabecular bone maintenance and adaptation. J Biomech. April 2005;38(4):931-941.
1993	Felson DT, Zhang Y, Hannan MT, Anderson JJ. Effects of weight and body mass index on bone mineral density in men and women: the Framingham Study. J Bone Miner Res. May 1993;8(5):567-573.
1997	Burr DB. Muscle strength, bone mass, and age‐related bone loss. J Bone Miner Res. 1997;12(10):1547-1551.
1998	Tomkinson A, Gevers EF, Wit JM, Reeve J, Noble BS. The role of estrogen in the control of rat osteocyte apoptosis. J Bone Miner Res. August 1998;13(8):1243-1250.
1994	Aarden EM, Burger EH, Nijweide PJ. Function of osteocytes in bone. J Cell Biochem. July 1994;55(3):287-299.
1997	Tomkinson A, Reeve J, Shaw RW, Noble BS. The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. J Clin Endocrinol Metab. September 1997;82(9):3128-3135.
1998	Mansell JP, Bailey AJ. Abnormal cancellous bone collagen metabolism in osteoarthritis. J Clin Invest. April 15, 1998;101(8):1596-1603.
2000	Huiskes R, Ruimerman R, van Lenthe GH, Janssen JD. Effects of mechanical forces on maintenance and adaptation of form in trabecular bone. Nature. June 8, 2000;405(6787):704-706.
2002	Ehrlich PJ, Lanyon LE. Mechanical strain and bone cell function: a review. Osteoporos Int. September 2002;13(9):688-700.
1996	Hillam RA. Response of Bone to Mechanical Load and Alterations in Circulating Hormones [PhD thesis]. Bristol, UK: University of Bristol; October 1996.
2007	Yuan Y. The Differential Effects of Two Critical Osteoclastogenesis Stimulating Factors on Bone Biomechanics [PhD thesis]. Clemson, SC: Clemson University; May 2007.
2012	Slyfield CR Jr. The Biomechanics of Bone Turnover [PhD thesis]. Ithaca, NY: Cornell University; January 2012.
2007	Devlin MJ. Interactions of Estrogen, Strain, and Bone Growth: Implications for Human Skeletal Robusticity [PhD thesis]. Cambridge, MA: Harvard University; September 2007.
2002	Egerer AK. The Relationship Between the Osteonal Cement Line and Bone Strength [PhD thesis]. Loma Linda University; June 2002.
2008	Herman BC. Osteocytes and Activation of Bone Remodeling [PhD thesis]. Mount Sinai School of Medicine; 2008.
1992	Bloomfield SA. Site-Specific Changes in Bone Mass and Alterations in Calciotropic Hormones With Electrical Stimulation Exercise in Individuals With Chronic Spinal Cord Injury [PhD thesis]. The Ohio State University; 1992.
2008	Mulvihill BMC. Computational Investigation Into the Mechanoregulation of Osteoporosis [PhD thesis]. Trinity College Dublin; December 2008.
2005	Ruimerman R. Modeling and Remodeling in Bone Tissue [PhD thesis]. Eindhoven University of Technology; 2005.
1994	Fritton SP. Computational Simulation of Trabecular Bone Adaptation [PhD thesis]. Tulane University; January 1994.
1996	Bober MB. The Regulation of Gene Expression by Mechanical Stimulation and Parathyroid Hormone in Bone in Vivo [PhD thesis]. Tulane University; 1996.
2018	Synek A. Predicting Habitual Activities from Bone Architecture Using a Biomechanical Approach [PhD thesis]. Vienna University of Technology; 2018.
2006	Rouhi G. Theoretical Aspects of Bone Remodeling and Resorption Processes [PhD thesis]. Calgary, AB: University of Calgary; March 2006.