Tendon to bone healing: differences in biomechanical, structural, and compositional properties due to a range of activity levels

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Thomopoulos, S.¹; Williams, G. R.¹; Soslowsky, L. J.¹

Tendon to bone healing: differences in biomechanical, structural, and compositional properties due to a range of activity levels

J Biomech Eng. February 2003;125(1):106-113

©2003 ASME

Affiliations

¹McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104-6081
Abstract

Little knowledge exists about the healing process of the tendon to bone insertion, and hence little can be done to improve tissue healing. The goal of this study is to describe the healing of the supraspinatus tendon to its bony insertion under a variety of loading conditions. Tendons were surgically detached and repaired in rats. Rat shoulders were then immobilized, allowed cage activity, or exercised. Shoulders that were immobilized demonstrated superior structural (significantly higher collagen orientation), compositional (expression of extracellular matrix genes similar to the uninjured insertion), and quasilinear viscoelastic properties (A=0.30±0.10 MPa vs. 0.16±0.08 MPa, B=17.4±2.9 vs. 15.1±0.9, and τ₂=344±161s vs. 233±40 s) compared to those that were exercised, contrary to expectations. With this knowledge of the healing response, treatment modalities for rotator cuff tears can be developed.
Links

DOI: 10.1115/1.1536660

PubMed: 12661203

WoS: 000181244400012
History

Received: 2002-01

Revised: 2002-08

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2006	Thomopoulos S, Marquez JP, Weinberger B, Birman V, Genin GM. Collagen fiber orientation at the tendon to bone insertion and its influence on stress concentrations. J Biomech. 2006;39(10):1842-1851.
2004	Abramowitch SD, Woo SL-Y. An improved method to analyze the stress relaxation of ligaments following a finite ramp time based on the quasi-linear viscoelastic theory. J Biomech Eng. February 2004;126(1):92-97.
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