Porous scaffold design for tissue engineering

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Hollister, Scott J.¹

Porous scaffold design for tissue engineering

Nat Mater. July 2005;4(7):518-524

©2005 Nature Publishing Group

Affiliations

¹Scaffold Tissue Engineering Group, Departments of Biomedical Engineering, Surgery and Mechnical Engineering, 1107 Gerstacker Building, 2200 Bonisteel Boulevard, The University of Michigan, Ann Arbor, Michigan 41809, USA
Abstract

A paradigm shift is taking place in medicine from using synthetic implants and tissue grafts to a tissue engineering approach that uses degradable porous material scaffolds integrated with biological cells or molecules to regenerate tissues. This new paradigm requires scaffolds that balance temporary mechanical function with mass transport to aid biological delivery and tissue regeneration. Little is known quantitatively about this balance as early scaffolds were not fabricated with precise porous architecture. Recent advances in both computational topology design (CTD) and solid free-form fabrication (SFF) have made it possible to create scaffolds with controlled architecture. This paper reviews the integration of CTD with SFF to build designer tissue-engineering scaffolds. It also details the mechanical properties and tissue regeneration achieved using designer scaffolds. Finally, future directions are suggested for using designer scaffolds with in vivo experimentation to optimize tissue-engineering treatments, and coupling designer scaffolds with cell printing to create designer material/biofactor hybrids.
Links

DOI: 10.1038/nmat1421

PubMed: 16003400

WoS: 000230190900013

Cited Works (8)

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