The design of scaffolds for use in tissue engineering, II:​ rapid prototyping techniques

Yang, Shoufeng; Leong, Kah-Fai; Du, Zhaohui; Chua, Chee-Kai

Affiliations

¹Design Research Center, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore

Abstract

Tissue engineering (TE) is an important emerging area in biomedical engineering for creating biological alternatives for harvested tissues, implants, and prostheses. In TE, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three-dimension (3D). However, existing 3D scaffolds for TE proved less than ideal for actual applications because they lack mechanical strength, interconnected channels, and controlled porosity or pores distribution. In this paper, the authors review the application and advancement of rapid prototyping (RP) techniques in the design and creation of synthetic scaffolds for use in TE. We also review the advantages and benefits, and limitations and shortcomings of current RP techniques as well as the future direction of RP development in TE scaffold fabrication.

Links

DOI: 10.1089/107632702753503009

PubMed: 11886649

WoS: 000174157000001

Cited Works (2)

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Cited By (12)

Year	Entry
2003	Taboas JM, Maddox RD, Krebsbach PH, Hollister SJ. Indirect solid free form fab.rication of local and global porous, biomimetic and composite 3d polymer-ceramic scaffolds. Biomaterials. January 2003;24(1):181-194.
2005	Hollister SJ. Porous scaffold design for tissue engineering. Nat Mater. July 2005;4(7):518-524.
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2009	Moesen M. Modeling of the Geometry and Mechanical Behavior of Bone Scaffolds [PhD thesis]. Katholieke Universiteit Leuven; June 2009.
2006	Jongpaiboonkit L. Calcium Phosphate Scaffolds for Bone Tissue Engineering and Self-Association PEG-PLLA Diblock Copolymer for Controlled Drug Delivery System [PhD thesis]. University of Michigan; 2006.
2007	Liao EE. Enhancement of Chondrogenesis by Directing Cellular Condensation Through Chondroinductive Microenvironments, And, Designed Solid Freeform Fabricated Scaffolds [PhD thesis]. University of Michigan; 2007.
2008	Kemppainen JM. Mechanically Stable Solid Freeform Fabricated Scaffolds With Permeability Optimized for Cartilage Tissue Engineering [PhD thesis]. University of Michigan; 2008.
2013	Pacheco Gómez HJ. Engineering Bioceramic Microstructure for Customized Drug Delivery [PhD thesis]. University of North Carolina at Charlotte; 2013.
2022	Blázquez Carmona P. Mechanobiology of Bone Regeneration: Distraction Osteogenesis and Tissue Engineering [PhD thesis]. Universidad de Sevilla; 2022.
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