3-D microarchitectural properties and rod- and plate-like trabecular morphometric properties of femur head cancellous bones in patients with rheumatoid arthritis, osteoarthritis, and osteoporosis

Ding, Ming<sup>1</sup>; Overgaard, Søren<sup>1,2</sup>

Affiliations

¹Orthopedic Research Laboratory, Department of Orthopedic Surgery & Traumatology, Odense University Hospital, And Department of Clinical Research, University of Southern Denmark, 5000, Odense, C, Denmark

²Department of Orthopaedic Surgery & Traumatology, Copenhagen University Hospital, Bispebjerg, And Department of Clinical Medicine, University of Copenhagen, 2400, Copenhagen, NV, Denmark

Abstract and keywords

Objectives: We quantify 3-D microarchitectural properties of femoral head cancellous bones from patients with rheumatoid arthritis (RA, n = 12), osteoarthritis (OA, n = 15), osteoporosis (OP, n = 24), or donor controls (CNT, n = 8); and investigate their rod- and plate-like trabecular morphometric properties of trabecular bone tissues and compare these properties between them.

Methods: Femoral heads were harvested during total hip replacement surgeries or collected from donors. Four cubic cancellous bone samples produced from each femoral head were micro-CT scanned to quantify their microarchitectural and rod- and plate-like trabecular properties. The samples were then tested in compression to determine mechanical properties.

Results: The microarchitectural properties of femoral head cancellous bone revealed significant differences among the 4 groups, but not between RA and OA. Bone volume fraction was significantly greater in the RA and the OA than in the OP and the CNT. Structure model index was significantly lower in the RA and the OA than in the OP. Number of rods in the RA was significantly greater than in the other 3 groups. Number of plates and plate volume density in the RA and the OA were significantly greater than in the OP and the CNT. Mechanical properties were significantly greater in the RA and the OA than in the OP. The single best determinant for mechanical properties was bone volume fraction.

Conclusions: This study demonstrates significant differences in 3-D microarchitectural properties and rod- and plate-like trabecular morphometric properties among patients with RA, OA, or OP. The RA and OA cancellous bones displayed similar patterns of microarchitectural degeneration and pronounced different microarchitectures from the OP. The OP group revealed the weakest cancellous bone strength, while the RA and OA groups exhibited a compensatory effect that maintains bone tissues, and hence mechanical properties.

The translational potential of this article: The study enhances the understanding of microarchitectural degeneration of diseased cancellous bone. The OP group had the weakest cancellous bone strength, while the RA and OA groups exhibited a compensatory effect that maintains bone tissues, and hence mechanical properties. These results are particularly important for design and survival of joint prosthesis.

Keywords: Rod- and plate-like trabeculae; Microarchitectural properties; Rheumatoid arthritis; Osteoarthritis; Osteoporosis; Mechanical properties

Links

DOI: 10.1016/j.jot.2021.02.002

PubMed: 33996461

WoS: 000658693500004

History

Received: 2020-12-13

Revised: 2021-01-28

Accepted: 2021-02-03

Online: 2021-04-20

Cited Works (13)

Year	Entry
2008	Liu XS, Sajda P, Saha PK, Wehrli FW, Bevill G, Keaveny TM, Guo XE. Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone. J Bone Miner Res. February 2008;23(2):223-235.
1997	Ding M, Dalstra M, Danielsen CC, Kabel J, Hvid I, Linde F. Age variations in the properties of human tibial trabecular bone. J Bone Joint Surg. November 1997;79B(6):995-1002.
2016	Black DM, Rosen CJ. Postmenopausal osteoporosis. NEJM. January 21, 2016;374(3):254-262.
1999	Ding M, Odgaard A, Hvid I. Accuracy of cancellous bone volume fraction measured by micro-CT scanning. J Biomech. 1999;32(3):323-326.
1993	Odgaard A, Gundersen HJG. Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions. Bone. March–April 1993;14(2):173-182.
1990	Odgaard A, Jensen EB, Gundersen HJG. Estimation of structural anisotropy based on volume orientation: a new concept. J Microsc (Oxford). February 1990;157(pt 2):149-162.
1997	Hildebrand T, Rüegsegger P. Quantification of bone microarchitecture with the structure model index. Comput Methods Prog Biomed. 1997;1(1):15-23.
2006	Stauber M, Müller R. Volumetric spatial decomposition of trabecular bone into rods and plates: a new method for local bone morphometry. Bone. 2006;38(4):475-484.
1997	Hildebrand T, Rüegsegger P. A new method for the model-independent assessment of thickness in three-dimensional images. J Microsc (Oxford). 1997;185(1):67-75.
2020	He Z, Chu L, Liu X, Han X, Zhang K, Yan M, Li X, Yu Z. Differences in subchondral trabecular bone microstructure and finite element analysis-based biomechanical properties between osteoporosis and osteoarthritis. J Orthop Translat. September 2020;24:3945.
2006	Stauber M, Rapillard L, van Lenthe GH, Zysset P, Müller R. Importance of individual rods and plates in the assessment of bone quality and their contribution to bone stiffness. J Bone Miner Res. April 2006;21(4):586-595.
2003	Seeman E. Reduced bone formation and increased bone resorption: rational targets for the treatment of osteoporosis. Osteoporos Int. March 2003;14(suppl 3):S2-S8.
2012	Burr DB, Gallant MA. Bone remodelling in osteoarthritis. Nat Rev Rheumatol. November 2012;8(11):665-673.

Cited By (1)

Year	Entry
2024	Schadow JE, Maxey D, Smith TO, Finnilä MA, Manske SL, Segal NA, Wong AKO, Davey RA, Turmezei T, Stok KS. Systematic review of computed tomography parameters used for the assessment of subchondral bone in osteoarthritis. Bone. January 2024;178:116948.