The role of growth factors in the repair of bone:​ biology and clinical applications

Lieberman, Jay R.; Daluiski, Aaron; Einhorn, Thomas A.

Affiliations

¹Department of Orthopaedic Surgery, UCLA Medical Center, CHS 76-134, 10833 Le Conte Avenue, Los Angeles, CA 90077

²Desert Orthopaedic Center, 3150 North Tenaya Way, Suite 405, Las Vegas, NV 89128

³Doctors Office Building, Suite 808, Boston University School of Medicine, 720 Harrison Avenue, Boston, MA 02118-2393

Links

DOI: 10.2106/00004623-200206000-00022

PubMed: 12063342

WoS: 000176174100022

Cited Works (5)

Year	Entry
1989	Younger EM, Chapman MW. Morbidity at bone graft donor sites. J Orthop Trauma. September 1989;3(3):192-195.
1999	Barnes GL, Kostenuik PJ, Gerstenfeld LC, Einhorn TA. Growth factor regulation of fracture repair. J Bone Miner Res. November 1999;14(11):1805-1815.
1988	Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA. Novel regulators of bone formation: molecular clones and activities. Science. December 16, 1988;242(4885):1528-1534.
1992	Yasko AW, Lane JM, Fellinger EJ, Wozney JM, Wang EA. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2): a radiographic, histological, and biomechanical study in rats. J Bone Joint Surg. June 1992;74A(5):659-670.
1965	Urist MR. Bone: formation by autoinduction. Science. November 12, 1965;150(3698):893-899.

Cited By (30)

Year	Entry
2005	Li W-J, Tuli R, Okafor C, Derfoul A, Danielson KG, Hall DJ, Tuan RS. A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials. February 2005;26(6):599-609.
2011	Boerckel JD, Kolambkar YM, Dupont KM, Uhrig BA, Phelps EA, Stevens HY, García AJ, Guldberg RE. Effects of protein dose and delivery system on BMP-mediated bone regeneration. Biomaterials. November 2011;32(22):5241-5251.
2004	Simmons CA, Alsberg E, Hsiong S, Kim WJ, Mooney DJ. Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone. August 2004;35(2):562-569.
2011	Kolambkar YM, Boerckel JD, Dupont KM, Bajin M, Huebsch N, Mooney DJ, Hutmacher DW, Guldberg RE. Spatiotemporal delivery of bone morphogenetic protein enhances functional repair of segmental bone defects. Bone. September 2011;49(4):485-492.
2020	Yang S-S, Oh J-M, Chun S, Kim B-S, Kim CS, Lee J. Tauroursodeoxycholic acid induces angiogenic activity in endothelial cells and accelerates bone regeneration. Bone. January 2020;130:115073.
2023	Priddy LB, Krishnan L, Hettiaratchi MH, Karthikeyakannan S, Gupte N, Guldberg RE. Amniotic membrane attenuates heterotopic ossification following high-dose bone morphogenetic protein-2 treatment of segmental bone defects. J Orthop Res. January 2023;41(1):130-140.
2013	Willett NJ, Li M-TA, Uhrig BA, Boerckel JD, Huebsch N, Lundgren TL, Warren GL, Guldberg RE. Attenuated human bone morphogenetic protein-2–mediated bone regeneration in a rat model of composite bone and muscle injury. Tissue Eng Part C Methods. April 2013;19(4):316-325.
2004	Pearson OM, Lieberman DE. The aging of Wolff's “law”: ontogeny and responses to mechanical loading in cortical bone. Yearb Phys Anthropol. 2004;47:63-99.
2017	McCorry MC. Tissue Engineering the Meniscus for Clinical Translation: Stem Cells, Fibers, and Attachments [PhD thesis]. Ithaca, NY: Cornell University; August 2017.
2005	Murray AW. Fracture Healing in Osteopenic Bone and the Influence of Simvastatin [MD thesis]. Edinburgh, Scotland: University of Edinburgh; 2005.
2007	Phillips JE. Runx2-Genetically Engineered Dermal Fibroblasts for Orthopaedic Tissue Repair [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2007.
2009	Deutsch ER. The Use of Stem Cell Synthesized Extracellular Matrix for Bone Repair [Master's thesis]. Atlanta, GA: Georgia Institute of Technology; December 2009.
2009	Kolambkar YM. Electrospun Nanofiber Meshes for the Functional Repair of Bone Defects [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2009.
2010	Dupont KM. Human Stem Cell Delivery and Programming for Functional Regeneration of Large Segmental Bone Defects [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2010.
2010	Johnson MR. Delivery of BMP-2 for Bone Tissue Engineering Applications [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2010.
2011	Boerckel JD. Mechanical Regulation of Bone Regeneration and Vascular Growth in Vivo [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2011.
2015	Li MT. Treatment Strategy for Composite Tissue Limb Trauma [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2015.
2015	Priddy LB. Biomaterial Strategies for Improved Bone Healing With Bone Morphogenetic Protein-2 Delivery [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2015.
2017	Shah FA. Osteocytes as Indicators of Bone Quality: Multiscale Structure-Composition Characterisation of the Bone-Implant Interface [PhD thesis]. University of Gothenburg; 2017.
2009	Lan SK. Multi-Scale Osteointegration and Neovascularization of Biphasic Calcium Phosphate Bone Scaffolds [PhD thesis]. University of Illinois at Urbana-Champaign; 2009.
2007	Geris L. Mathematical Modelling of Bone Regeneration During Fracture Healing and Implant Osseointegration [PhD thesis]. Katholieke Universiteit Leuven; May 2007.
2015	Damaraju SM. Piezoelectric Scaffolds for Osteochondral Defect Repair [PhD thesis]. New Jersey Institute of Technology; May 2015.
2010	Gurkan UA. Engineering of Bone Marrow in Vitro for Investigating the Role of Growth Factors and Their Mechanoresponsiveness in Osteogenesis [PhD thesis]. Purdue University; May 2010.
2004	De Ranieri A. Morphologic, Mechanical, and Molecular Aspects of TGF-Β2 Enhanced Implant Fixation [PhD thesis]. Rush University; 2004.
2012	Hu M. Mitigation of Bone Loss and Augment of Anabolic Adaptation by Physiological Dynamic Fluid Flow Stimulation [PhD thesis]. Stony Brook, NY: Stony Brook University; December 2012.
2007	Isaksson HE. Mechanical and Mechanobiological Influences on Bone Fracture Repair: Identifying Important Cellular Characteristics [PhD thesis]. Eindhoven, The Netherlands: Eindhoven University of Technology; 2007.
2013	Soicher MA. Fabrication and Characterization of Remineralized Bone Matrices (RBM) for Use as Bone Tissue Engineering Substrates [PhD thesis]. Davis, University of California; 2013.
2004	Lin C-Y. A New Spine Interbody Fusion System: Integrating Topology Optimized Biodegradable Interbody Fusion Cages With Cell-Based and Ex Vivo Gene Therapy [PhD thesis]. University of Michigan; 2004.
2007	Wu Y-L. Interaction of Bone Cells With Biomimetic Hydroxyapatite Gelatin Nanocomposites Towards Developing Bone Tissue Engineering [PhD thesis]. University of Minnesota; December 2007.
2016	Collins CJ. A Comprehensive Evaluation of Methods to Determine Mechanical Properties of Long Bone [PhD thesis]. University of Wisconsin – Madison; 2016.