FRAX<sup>®</sup> and its applications to clinical practice

Kanis, John A.<sup>1</sup>; Oden, Anders<sup>1</sup>; Johansson, Helena<sup>1</sup>; Borgström, Fredrik<sup>1</sup>; Ström, Oskar<sup>1</sup>; McCloskey, Eugene<sup>1</sup>

Affiliations

¹WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, UK

Abstract and keywords

The introduction of the WHO FRAX^® algorithms has facilitated the assessment of fracture risk on the basis of fracture probability. FRAX^® integrates the influence of several well validated risk factors for fracture with or without the use of BMD. Its use in fracture risk prediction poses challenges for patient assessment, the development of practice guidelines, the evaluation of drug efficacy and reimbursement, as well as for health economics which are the topics outlined in this review.

Keywords: FRAX®; Fracture probability; Risk assessment; Cost-effectiveness; Efficacy

Links

DOI: 10.1016/j.bone.2009.01.373

PubMed: 19195497

WoS: 000265436000001

History

Received: 2008-12-2

Revised: 2009-01-21

Accepted: 2009-01-21

Online: 2009-02-2

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