Sacrificial bonds in the interfibrillar matrix of bone

Hansma, P. K.; Fantner, G. E.; Kindt, J. H.; Thurner, P. J.; Schitter, G.; Turner, P. J.; Udwin, S. F.; Finch, M. M.

Affiliations

¹Department of Physics, University of California, Santa Barbara, CA, USA

Keywords

Keywords: Bone; Fracture Resistance; Noncollagenous Proteins; Molecular Sacrificial Bonds; Atomic Force Microscopy

Links

PubMed: 16340118

History

Accepted: 2005-07-31

Cited Works (6)

Year	Entry
1988	Jackson AP, Vincent JFV, Turner RM. The mechanical design of nacre. Proc R Soc B. September 22, 1988;234(1277):415-440.
1999	Smith BL, Schäffer TE, Viani M, Thompson JB, Frederick NA, Kindt J, Belcher A, Stucky GD, Morse DE, Hansma PK. Molecular mechanistic origin of the toughness of natural adhesives, fibres and composites. Nature. June 24, 1999;399(6738):761-763.
1977	Currey JD. Mechanical properties of mother of pearl in tension. Proc R Soc Lond B Biol Sci. 1977;196(1125):443-463.
2005	Fantner GE, Hassenkam T, Kindt JH, Weaver JC, Birkedal H, Pechenik L, Cutroni JA, Cidade GAG, Stucky GD, Morse DE, Hansma PK. Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture. Nat Mater. August 2005;4(8):612-616.
2001	Thompson JB, Kindt JH, Drake B, Hansma HG, Morse DE, Hansma PK. Bone indentation recovery time correlates with bond reforming time. Nature. December 13, 2001;414(6865):773-776.
2004	Hassenkam T, Fantner G, Cutroni J, Weaver J, Morse D, Hansma P. High-resolution AFM imaging of intact and fractured trabecular bone. Bone. July 2004;35(1):4-10.

Cited By (28)

Year	Entry
2011	Wang R, Gupta HS. Deformation and fracture mechanisms of bone and nacre. Ann Rev Mater Res. August 2011;41:41-73.
2010	Reisinger AG, Pahr DH, Zysset PK. Sensitivity analysis and parametric study of elastic properties of an unidirectional mineralized bone fibril-array using mean field methods. Biomech Model Mechanobiol. October 2010;9(5):499-510.
2005	Seref-Ferlengez Z, Kennedy OD, Schaffler MB. Bone microdamage, remodeling and bone fragility: how much damage is too much damage? BoneKEy Rep. March 18, 2005;4:644.
2015	Seref-Ferlengez Z, Kennedy OD, Schaffler MB. Bone microdamage, remodeling and bone fragility: how much damage is too much damage? BoneKEy Rep. March 2015;4:644.
2020	Maghsoudi-Ganjeh M, Wang X, Zeng X. Nanomechanics and ultrastructure of bone: a review. Comput Model Eng Sci. 2020;125(1):1-32.
2020	Kraiem T, Barkaoui A, Merzouki T, Chafra M. Computational approach of the cortical bone mechanical behavior based on an elastic viscoplastic damageable constitutive model. Int J Appl Mech. 2020;2(7):2050081.
2007	Duvall CL, Taylor WR, Weiss D, Wojtowicz AM, Guldberg RE. Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin‐deficient mice. J Bone Miner Res. February 2007;22(2):286-297.
2019	Asgari M, Abi-Rafeh J, Hendy GN, Pasini D. Material anisotropy and elasticity of cortical and trabecular bone in the adult mouse femur via AFM indentation. J Mech Behav Biomed Mater. May 2019;93:81-92.
2020	Maghsoudi-Ganjeh M, Wang X, Zeng X. Computational investigation of the effect of water on the nanomechanical behavior of bone. J Mech Behav Biomed Mater. January 2020;101:103454.
2007	Gupta HS, Fratzl P, Kerschnitzki M, Benecke G, Wagermaier W, Kirchner HOK. Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV. J R Soc Interface. April 22, 2007;4(3):277-282.
2008	Gupta HS, Zioupos P. Fracture of bone tissue: the ‘hows’ and the ‘whys’. Med Eng Phys. December 2008;30(10):1209-1226.
2012	Poundarik AA, Diab T, Sroga GE, Ural A, Boskey AL, Gundberg CM, Vashishth D. Dilatational band formation in bone. Proc Natl Acad Sci USA. November 20, 2012;109(47):19178-19183.
2019	Tertuliano OA. Small-Scale Deformation and Fracture of Hard Biomaterials [PhD thesis]. Pasadena, CA: California Institute of Technology; 2019.
2017	Unal M. Classification of Bound Water and Collagen Denaturation Status of Cortical Bone by Raman Spectroscopy [PhD thesis]. Cleveland, OH: Case Western Reserve University; January 2017.
2020	Mehraban Alvandi L. Diffuse Damage Repair Mechanism in Bone [PhD thesis]. New York, NY: The City College of New York; 2020.
2014	Seref-Ferlengez Z. Diffused Microdamage in Bone Vivo: Structural and Mechanical Bases of Repair [PhD thesis]. New York, NY: The City University of New York; 2014.
2022	Peruzzi CRP. Nanoscale Deformation Mechanisms and Yield Prediction of Lamellar Bone [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2022.
2007	Duvall CL. The Role of Osteopontin in Postnatal Vascular Growth: Functional Effects in Ischemic Limb Collateral Vessel Formation and Long Bone Fracture Healing [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2007.
2019	Nobakhti S. Multiscale Characteristics of Bone Toughness [PhD thesis]. Northeastern University; July 2019.
2020	O’Sullivan LM. Time-Sequence of Biomechanical Adaption in Trabecular Tissue During Estrogen Deficiency [PhD thesis]. National University of Ireland Galway; March 2020.
2012	Sun X. Mechanically Induced Calcium Efflux from Bone Matrix Stimulates Osteoblasts [PhD thesis]. Purdue University; May 2012.
2013	Poundarik A. The Role of Non-Collagenous Proteins, in Particular, Osteocalcin and Osteopontin, in the Determination of Bone Matrix Quality [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; May 2013.
2016	Bailey SM. The Role of Extra-Cellular Matrix Proteins and Post-Translational Modifications on Bone Fracture [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; September 2016.
2008	Mulvihill BMC. Computational Investigation Into the Mechanoregulation of Osteoporosis [PhD thesis]. Trinity College Dublin; December 2008.
2011	Reisinger AG. Modeling and Validation of Multiscale Lamellar Bone Elasticity [PhD thesis]. Vienna University of Technology; November 2011.
2012	Hardisty MR. Not Tough Enough: Why Bone Turns Pale When it Feels Stressed [PhD thesis]. Davis, CA: Davis, University of California; 2012.
2014	Schwiedrzik JJ. Experimental, Theoretical and Numerical Investigation of the Nonlinear Micromechanical Properties of Bone [PhD thesis]. Universität Bern; 2014.
2020	Maghsoudi-Ganjeh M. Computational Investigation of Ultrastructural Behavior of Bone and Bone-Inspired Materials [PhD thesis]. San Antionio, TX: University of Texas at San Antonio; May 2020.