Nanoscale ion mediated networks in bone:​ osteopontin can repeatedly dissipate large amounts of energy

Fantner, Georg E.; Adams, Jonathan; Turner, Patricia; Thurner, Philipp J.; Fisher, Larry W.; Hansma, Paul K.

Affiliations

¹University of California Santa Barbara, Department of Physics, Santa Barbara, California 93106

²Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892

Abstract

In the nanocomposite bone, inorganic material is combined with several types of organic molecules, and these complexes have been proposed to increase the bone strength. Here we report on a mechanism of how one of these components, human osteopontin, forms large mechanical networks that can repeatedly dissipate energy through work against entropy by breaking sacrificial bonds and stretching hidden length. The behavior of these in vitro networks is similar to that of organic components in bone, acting as an adhesive layer in between mineralized fibrils.

Links

DOI: 10.1021/nl0712769

PubMed: 17645366

WoS: 000248657800057

History

Received: 2007-05-30

Revised: 2007-07-09

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