Flow effects on prostacyclin production by cultured human endothelial cells

Frangos, John A.; Eskin, Suzanne G.; McIntire, Larry V.; Ives, C. L.

Affiliations

¹Biomedical Engineering Laboratory, Department of Chemical Engineering, Rice University, Houston, Texas 77251

²Department of Surgery, Baylor College of Medicine, Houston, Texas 77030

³Biomedical Engineering Laboratory, Department of Chemical Engineering, Rice University

Abstract and keywords

Endothelial cell functions, such as arachidonic acid metabolism, may be modulated by membrane stresses induced by blood flow. The production of prostacyclin by primary human endothelial cell cultures subjected to pulsatile and steady flow shear stress was measured. The onset of flow led to a sudden increase in prostacyclin production, which decreased to a steady rate within several minutes. The steady-state production rate of cells subjected to pulsatile shear stress was more than twice that of cells exposed to steady shear stress and 16 times greater than that of cells in stationary culture.

Keywords:

Links

DOI: 10.1126/science.3883488

PubMed: 3883488

WoS: A1985ADG0600027

History

Received: 1984-09-07

Accepted: 1984-12-21

Cited Works (1)

Year	Entry
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Cited By (47)

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