Bone marrow, cytokines, and bone remodeling:​ emerging insights into the pathophysiology of osteoporosis

Manolagas, Stavros C.; Jilka, Robert L.

Affiliations

¹Division of Endocrinology and Metabolism, Department of Internal Medicine, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, and the McClellan Veterans Affairs Medical Center

Links

DOI: 10.1056/NEJM199502023320506

PubMed: 7816067

WoS: A1995QD39600006

Cited Works (7)

Year	Entry
1990	Parfitt AM. Bone-forming cells in clinical conditions. In: Hall BK, ed. Bone. Volume 1: The Osteoblast and Osteocyte. Caldwell, NJ: Inc., The Telford Press; 1990:351-429.
1993	Balena R, Toolan BC, Shea M, Markatos A, Myers ER, Lee SC, Opas EE, Seedor JG, Klein H, Frankenfield D, Quartuccio H, Fioravanti C, Clair J, Brown E, Hayes WC, Rodan GA. The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. J Clin Invest. December 1993;92(6):2577-2586.
1994	Parfitt AM. Osteonal and hemi‐osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem. July 1994;55(3):273-286.
1990	Eriksen EF, Hodgson SF, Eastell R, Cedel SL, O'Fallon WM, Riggs BL. Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels. J Bone Miner Res. April 1990;5(4):311-319.
1991	Kalu DN. The ovariectomized rat model of postmenopausal bone loss. Bone Miner. December 1991;15(3):175-191.
1992	Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science. July 3, 1992;257(5066):88-91.
1986	Dempster DW, Shane E, Horbert W, Lindsay R. A simple method for correlative light and scanning electron microscopy of human iliac crest bone biopsies: qualitative observations in normal and osteoporotic subjects. J Bone Miner Res. February 1986;1(1):15-21.

Cited By (35)

Year	Entry
2011	Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol. 2011;6:121-145.
2007	Tatsumi S, Ishii K, Amizuka N, Li M, Kobayashi T, Kohno K, Ito M, Takeshita S, Ikeda K. Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab. June 2007;5(6):464-475.
2000	Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. April 2000;21(2):115-137.
1998	Bucay N, Sarosi I, Dunstan CR, Morony S, Tarpley J, Capparelli C, Scully S, Tan HL, Xu W, Lacey DL, Boyle WJ, Simonet WS. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. May 1998;12(9):1260-1268.
1996	Parfitt AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF. A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res. February 1996;11(2):150-159.
1997	Han Z-H, Palnitkar S, Rao DS, Nelson D, Parfitt AM. Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: implications for mechanisms of bone loss. J Bone Miner Res. April 1997;12(4):498-508.
1998	Riggs BL, Khosla S, Melton LJ III. A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res. May 1998;13(5):763-773.
1998	Jilka RL, Weinstein RS, Bellido T, Parfitt AM, Manolagas SC. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J Bone Miner Res. May 1998;13(5):793-802.
2020	Hain BA, Jude B, Xu H, Smuin DM, Fox EJ, Elfar JC, Waning DL. Zoledronic acid improves muscle function in healthy mice treated with chemotherapy. J Bone Miner Res. February 2020;35(2):368-381.
2020	Zheng J, Brion M, Kemp JP, Warrington NM, Borges M, Hemani G, Richardson TG, Rasheed H, Qiao Z, Haycock P, Ala‐Korpela M, Smith GD, Tobias JH, Evans DM. The effect of plasma lipids and lipid‐lowering interventions on bone mineral density: a Mendelian randomization study. J Bone Miner Res. July 2020;35(7):1224-1235.
1998	Mansell JP, Bailey AJ. Abnormal cancellous bone collagen metabolism in osteoarthritis. J Clin Invest. April 15, 1998;101(8):1596-1603.
1999	Jilka RL, Weinstein RS, Bellido T, Roberson P, Parfitt AM, Manolagas SC. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J Clin Invest. August 1999;104(4):439-446.
2001	Jee WSS, Yao W. Overview: animal models of osteopenia and osteoporosis. J Musculoskel Neuron Interact. March 2001;1(3):193-207.
1999	Kong Y-Y, Yoshida H, Sarosi I, Tan H-L, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. January 28, 1999;397(6717):315-323.
2012	Khosla S, Oursler MJ, Monroe DG. Estrogen and the skeleton. Trends Endocrinol Metab. November 2012;23(11):576-581.
2007	Yuan Y. The Differential Effects of Two Critical Osteoclastogenesis Stimulating Factors on Bone Biomechanics [PhD thesis]. Clemson, SC: Clemson University; May 2007.
2019	Campi AE. Mechanosensitive Ca²⁺ Signaling of Ex Vivo Osteocytes in Aging and Treatment [PhD thesis]. Columbia University; 2019.
2015	Brock GR Jr. Changes in Bone Tissue Properties With Osteoporosis Treatment [PhD thesis]. Ithaca, NY: Cornell University; January 2015.
2015	Goff M. The Role of Micro and Ultra-Structure in Microdamage Accumulation in Cancellous Bone [PhD thesis]. Ithaca, NY: Cornell University; August 2015.
2017	Matheny JB. Interactions Between Bone Remodeling and Microdamage in Cancellous Bone [PhD thesis]. Ithaca, NY: Cornell University; August 2017.
2005	Murray AW. Fracture Healing in Osteopenic Bone and the Influence of Simvastatin [MD thesis]. Edinburgh, Scotland: University of Edinburgh; 2005.
2011	Lambers FM. Functional Bone Imaging in an in Vivo Mouse Model of Bone Adaptation, Aging and Disease [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2011.
2019	Lambert C. A Comparison of the Bone Response to Impact Loading and Resistance Training in Young Adult Women: The OPTIMA-Ex Trial [PhD thesis]. Brisbane, Australia: Griffith University; July 2019.
2000	Richman CC. In Vitro and in Vivo Studies on Bone Formation [PhD thesis]. Loma Linda University; March 2000.
2003	Duque G. Molecular Changes in the Aging Osteoblast [PhD thesis]. McGill University; March 2003.
2017	Kreipke TC. Structural, Mechanical, and Biological Relationships of Trabecular Bone in Osteoporosis [PhD thesis]. University of Notre Dame; April 2017.
2010	Boyle CH. Computational Study of Wolff's Law Utilizing Design Space Topology Optimization: A New Method for Hip Prosthesis Design [Master's thesis]. Queen's University; August 2010.
2013	Irish JM. Peri-Implant Bone Turnover in a Rat Model [Master's thesis]. Rush University; 2013.
2010	Trinward A. Osteoporosis Drugs Prevent Bone Loss, Normalize Metabolic Parameters and Negatively Correlate Bone and Fat [Master's thesis]. Stony Brook, NY: Stony Brook University; 2010.
2011	Appiah-Nkansah K. Integration of Refractory Periods in the Administration of Low-Magnitude Mechanical Signals Increases Mesenchymal Stem Cell Numbers in the Bone Marrow [Master's thesis]. Stony Brook, NY: Stony Brook University; May 2011.
2014	Nour MA. Impact of Growth Hormone on Adult Bone Quality in Turner Syndrome: A High Resolution Peripheral Quantitative Computed Tomography Study [Master's thesis]. Calgary, AB: University of Calgary; January 2014.
2010	Alberich Bayarri Á. In Vivo Morphometric and Mechanical Characterization of Trabecular Bone from High Resolution Magnetic Resonance Imaging [PhD thesis]. Universität Politècnica de València; 2010.
2021	Harrison KD. A Novel in Vivo Synchrotron Radiation Micro-CT Imaging Platform for the Direct Tracking of Remodeling Events in Cortical Bone [PhD thesis]. University of Saskatchewan; December 2021.
2012	Hamidi MS. Dietary Factors and Bone Health in Postmenopausal Women [PhD thesis]. University of Toronto; 2012.
2016	Vachhani KJ. A Pre-Clinical Assessment of Lithium to Enhance Fracture Healing in Healthy and Impaired Bone Rat Model [Master's thesis]. University of Toronto; 2016.