Effect of intraspecimen spatial variation in tissue mineral density on the apparent stiffness of trabecular bone

Kaynia, Narges; Soohoo, Elaine; Keaveny, Tony M.; Kazakia, Galateia J.

Affiliations

¹Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

²Department of Mechanical Engineering, University of California, Berkeley, CA 94720

³Department of Bioengineering, University of California, Berkeley, CA 94720

⁴Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107

Abstract and keywords

This study investigated the effects of intraspecimen variations in tissue mineral density (TMD) on the apparent-level stiffness of human trabecular bone. High-resolution finite element (FE) models were created for each of 12 human trabecular bone specimens, using both microcomputed tomography (μCT) and “gold-standard” synchrotron radiation μCT (SRμCT) data. Our results confirm that incorporating TMD spatial variation reduces the calculated apparent stiffness compared to homogeneous TMD models. This effect exists for both μCT- and SRμCT-based FE models, but is exaggerated in μCT-based models. This study provides a direct comparison of μCT to SRμCT data and is thereby able to conclude that the influence of including TMD heterogeneity is overestimated in μCT-based models.

Keywords: trabecular bone; tissue mineral density; heterogeneity; finite element analysis; microcomputed tomography; synchrotron; mechanical properties; apparent modulus

Links

DOI: 10.1115/1.4029178

PubMed: 25412197

WoS: 000346341300013

History

Received: 2014-08-05

Revised: 2014-11-17

Accepted: 2014-12-10

Online: 2014-12-10

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Cited By (4)

Year	Entry
2018	Wu D, Isaksson P, Ferguson SJ, Persson C. Young’s modulus of trabecular bone at the tissue level: a review. Acta Biomater. September 15, 2018;78:1.
2018	Hammond MA, Wallace JM, Allen MR, Siegmund T. Incorporating tissue anisotropy and heterogeneity in finite element models of trabecular bone altered predicted local stress distributions. Biomech Model Mechanobiol. April 2018;17(2):605-614.
2016	Chen Y. Verification and Validation of MicroCT-Based Finite Element Models of Bone Tissue Biomechanics [PhD thesis]. Sheffield, UK: University of Sheffield; July 2016.
2020	Belda González R. Mechanical and Morphometric Characterization of Cancellous Bone [PhD thesis]. Universität Politècnica de València; March 2020.