The numerous mathematical models of human body behaviour in traffic accidents, which have been developed during last years, are not so much used as one could suppose, considering all their advantages in relation to experimental tests, notably their very low operating cost. Their main handicap is generally an insufficient validation, involving a lack of reliance of users, toward the results supplied by mathematical models. The originality of PRAKIMOD, the model developed in the Laboratory of Physiology and Biomechanics of Peugeot S.A./Renault is that it has formed the subject, in pedestrian configuration, of a systematic validation. This validation carried out by comparison of PRAKIMOD simulations of car-to-pedestrian collisions, with different vehicles at different speeds, to experimental collisions performed under the same conditions, is presented in this paper, as also two examples of applications.