Injury and repair of ligaments and tendons

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Woo, Savio L.-Y.¹; Debski, Richard E.¹; Zeminski, Jennifer¹; Abramowitch, Steven D.¹; Chan Saw, Serena S. ¹; Fenwick, James A.¹

Injury and repair of ligaments and tendons

Annu Rev Biomed Eng. 2000;2:83-118

©2000 Annual Reviews. All rights reserved.

Affiliations

¹Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
Abstract and keywords

In this chapter, biomechanical methods used to analyze healing and repair of ligaments and tendons are initially described such that the tensile properties of these soft tissues as well as their contribution to joint motion can be determined. The focus then turns to the important mechanical and biological factors that improve the healing process of ligaments. The biomechanics of surgical reconstruction of the anterior cruciate ligament and the key surgical parameters that affect the performance of the replacement grafts are subsequently reviewed. Finally, injury mechanisms and the biomechanical analysis of various treatment techniques for various types of tendon injuries are described.

Keywords: tensile properties, kinematics, knee, reconstruction, healing
Links

DOI: 10.1146/annurev.bioeng.2.1.83

PubMed: 11701508

WoS: 000089887400005

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2023	Lake SP, Snedeker JG, Wang VM, Awad H, Screen HRC, Thomopoulos S. Guidelines for ex vivo mechanical testing of tendon. J Orthop Res. October 2023;41(10):2105-2113.
2023	Lane RA, Migotsky N, Havlioglu N, Iannucci LE, Shen H, Lake S, Sakiyama-Elbert SE, Thomopoulos S, Gelberman RH. The effects of NF-κB suppression on the early healing response following intrasynovial tendon repair in a canine model. J Orthop Res. October 2023;41(10):2295-2304.
2011	Eleswarapu SV, Responte DJ, Athanasiou KA. Tensile properties, collagen content, and crosslinks in connective tissues of the immature knee joint. PLoS One. October 2011;6(10):e26178.
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2010	Loghmani MT. The Effects of Instrument-Assisted Cross Fiber Massage on Ligament Healing [PhD thesis]. Indianapolis, IN: Indiana University; May 2010.
2011	Eleswarapu SV. Multiscale Strategies for Cartilage Repair [PhD thesis]. Houston, TX: Rice University; October 2011.
2011	Responte DJ. Novel Exogenous Agents for Improving Articular Cartilage Tissue Engineering [PhD thesis]. Houston, TX: Rice University; October 2011.
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2010	Ansorge HL. Development as a New Paradigm for Improved Tendon Healing: A Characterization of Neonatal Tendon Development, Healing During Development and an Investigation Into Differential Parameters During Accelerated Healing [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2010	Peltz CD. The Role of Altered Loading in Pathological Changes in the Long Head of the Biceps Tendon Following Rotator Cuff Tears in a Rat Model [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2011	Dourte LM. Relationships Between Decorin and Biglycan, Structure and Tendon Mechanics Using Mutant Mouse Models [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2011.
2012	Miller KS. Collagen Fiber Re-Alignment and Uncrimping in Response to Loading: Determining Structure-Function Relationships Using a Developmental Tendon Mouse Model [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2012.
2015	Connizzo BK. The Connection of Composition, Structure, and Dynamic Processes to Tendon Mechanics: Structure-Function Relationships in Collagen V Deficient Tendons [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.
2018	Riggin CN. Development and Utilization of Ultrasound Imaging Techniques to Evaluate the Role of Vascularity in Adult and Aged Rat Achilles Tendon Healing [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2018.
2012	Reese SP. Multiscale Structure-Function Relationships in the Mechanical Behavior of Tendon and Ligament [PhD thesis]. University of Utah; May 2012.
2009	Gregory DE. The Influence of the Tensile Material Properties of Single Annulus Fibrosus Lamellae and the Interlamellar Matrix Strength on Disc Herniation and Progression [PhD thesis]. University of Waterloo; 2009.
2011	Howarth SJ. Mechanical Response of the Porcine Cervical Spine to Acute and Repetitive Anterior-Posterior Shear [PhD thesis]. University of Waterloo; 2011.
2004	Dwyer KW. The Role of Neuropeptides in Neuropathic and Normal MCL Healing [PhD thesis]. University of Wisconsin – Madison; 2004.
2005	Olabisi OMR. Distraction Osteogenesis, Myogenesis and Fibrogenesis: An Investigation of the Maladaptation of the Soft Tissue in Response to Distraction and the Efficacy of Botulinum Toxin Type A as a Countermeasure [PhD thesis]. University of Wisconsin – Madison; 2005.