The purpose of this study was to investigate whether using a finite-element (FE) mesh composed entirely of hexahedral elements to model cortical and trabecular bone (all-hex model) would provide more accurate simulations than those with variable thickness shell elements for cortical bone and hexahedral elements for trabecular bone (hex–shell model) in the modeling human ribs. First, quasi-static non-injurious and dynamic injurious experiments were performed using the second, fourth, and tenth human thoracic ribs to record the structural behavior and fracture tolerance of individual ribs under anterior–posterior bending loads. Then, all-hex and hex–shell FE models for the three ribs were developed using an octree-based and multi-block hex meshing approach, respectively. Material properties of cortical bone were optimized using dynamic experimental data and the hex–shell model of the fourth rib and trabecular bone properties were taken from the literature. Overall, the reaction force–displacement relationship predicted by both all-hex and hex–shell models with nodes in the offset middle-cortical surfaces compared well with those measured experimentally for all the three ribs. With the exception of fracture locations, the predictions from all-hex and offset hex–shell models of the second and fourth ribs agreed better with experimental data than those from the tenth rib models in terms of reaction force at fracture (difference <15.4%), ultimate failure displacement and time (difference <7.3%), and cortical bone strains. The hex–shell models with shell nodes in outer cortical surfaces increased static reaction forces up to 16.6%, compared to offset hex–shell models. These results indicated that both all-hex and hex–shell modeling strategies were applicable for simulating rib responses and bone fractures for the loading conditions considered, but coarse hex–shell models with constant or variable shell thickness were more computationally efficient and therefore preferred.