The Application of Digital Volume Correlation Bone Strain Measurements in the Osteoarthritic Glenohumeral Joint

This thesis investigates the accuracy and precision of digital volume correlation measurements derived from micro-computed tomography imagery of interfaces in the upper extremity of clinical relevance, namely, the implant-cement-bone interface of glenoid implants used in total shoulder arthroplasties and the implant-bone interface of shoulder hemiarthroplasties. The works within derive relationships between measurement accuracy and precision and parameters of practical interest such as image quality and measurement spatial resolution. It also analyzes the effects of micro-computed tomography image artifact-inducing materials on the accuracy and precision of digital volume correlation-based measurements and the spatial relationship between distance between the artifacting material and the magnitude of change in accuracy and precision. Finally, it also contains an in-vitro model of the peripheral glenoid peg-cement-bone interface which is subsequently analyzed through digital volume correlation; the relationship between peg/bone region and strain magnitude is elucidated.

Keywords: Glenoid implants; digital volume correlation; micro-computed tomography; humeral head implants; trabecular bone strains; implant-cement-bone interfaces

Year	Entry
2004	Barrett JF, Keat N. Artifacts in CT: recognition and avoidance. RadioGraphics. November–December 2004;24(6):1679-1691.
2022	Buss DJ, Kröger R, McKee MD, Reznikov N. Hierarchical organization of bone in three dimensions: a twist of twists. J Struct Biol X. 2022;6:100057.
2001	Fajardo RJ, Müller R. Three‐dimensional analysis of nonhuman primate trabecular architecture using micro‐computed tomography. Am J Phys Anthropol. 2001;115(4):327-336.
2010	Cristofolini L, Schileo E, Juszczyk M, Taddei F, Martelli S, Viceconti M. Mechanical testing of bones: the positive synergy of finite–element models and in vitro experiments. Philos Trans R Soc A-Math Phys Eng Sci. June 13, 2010;368(1920):2725-2763.
2019	Kusins J, Knowles N, Ryan M, Dall’Ara E, Ferreira L. Performance of QCT-derived scapula finite element models in predicting local displacements using digital volume correlation. J Mech Behav Biomed Mater. September 2019;97:339-345.
1999	Bay BK, Smith TS, Fyhrie DP, Saad M. Digital volume correlation: three-dimensional strain mapping using X-ray tomography. Exp Mech. September 1999;39(3):217-226.
2015	Oftadeh R, Perez-Viloria M, Villa-Camacho JC, Vaziri A, Nazarian A. Biomechanics and mechanobiology of trabecular bone: a review. J Biomech Eng. January 2015;137(1):010802.
2019	Knowles NK, Kusins J, Faieghi M, Ryan M, Dall’Ara E, Ferreira LM. Material mapping of QCT-derived scapular models: a comparison with micro-CT loaded specimens using digital volume correlation. Ann Biomed Eng. November 2019;47(11):2188-2198.
2005	Nagaraja S, Couse TL, Guldberg RE. Trabecular bone microdamage and microstructural stresses under uniaxial compression. J Biomech. 2005;38(4):707-716.
2004	Bayraktar HH, Morgan EF, Niebur GL, Morris GE, Wong EK, Keaveny TM. Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue. J Biomech. January 2004;37(1):27-35.
2017	du Plessis A, Broeckhoven C, Guelpa A, le Roux SG. Laboratory x-ray micro-computed tomography: a user guideline for biological samples. GigaScience. June 2017;6(6):gix027.
2007	Liu L, Morgan EF. Accuracy and precision of digital volume correlation in quantifying displacements and strains in trabecular bone. J Biomech. 2007;40(15):3516-3520.
1989	Odgaard A, Hvid I, Linde F. Compressive axial strain distributions in cancellous bone specimens. J Biomech. 1989;22(8-9):829-835.
2019	Comini F, Palanca M, Cristofolini L, Dall’Ara E. Uncertainties of synchrotron microCT-based digital volume correlation bone strain measurements under simulated deformation. J Biomech. March 27, 2019;86:232-237.
2019	van Dijk NP, Wu D, Persson C, Isaksson P. A global digital volume correlation algorithm based on higher-order finite elements: implementation and evaluation. Int J Solids Struct. August 15, 2019;168:211-227.
2014	Dong P, Haupert S, Hesse B, Langer M, Gouttenoire P-J, Bousson V, Peyrin F. 3D osteocyte lacunar morphometric properties and distributions in human femoral cortical bone using synchrotron radiation micro-CT images. Bone. March 2014;60:172-185.
2006	Stauber M, Rapillard L, van Lenthe GH, Zysset P, Müller R. Importance of individual rods and plates in the assessment of bone quality and their contribution to bone stiffness. J Bone Miner Res. April 2006;21(4):586-595.
2001	Morgan EF, Keaveny TM. Dependence of yield strain of human trabecular bone on anatomic site. J Biomech. 2001;34(5):569-577.
1996	Cristofolini L, Viceconti M, Cappello A, Toni A. Mechanical validation of whole bone composite femur models. J Biomech. April 1996;29(4):525-535.
2017	Dall’Ara E, Peña-Fernández M, Palanca M, Giorgi M, Cristofolini L, Tozzi G. Precision of digital volume correlation approaches for strain analysis in bone imaged with micro-computed tomography at different dimensional levels. Front Mater. November 8, 2017;4:31.
2020	Turunen MJ, Le Cann S, Tudisco E, Lovric G, Patera A, Hall SA, Isaksson H. Sub-trabecular strain evolution in human trabecular bone. Sci Rep. 2020;10:13788.
2015	Grassi L, Isaksson H. Extracting accurate strain measurements in bone mechanics: a critical review of current methods. J Mech Behav Biomed Mater. October 2015;50:43-54.
2015	Palanca M, Tozzi G, Cristofolini L, Viceconti M, Dall'Ara E. Three-dimensional local measurements of bone strain and displacement: comparison of three digital volume correlation approaches. J Biomech Eng. July 2015;137(7):071006.
2016	Palanca M, Cristofolini L, Dall’Ara E, Curto M, Innocente F, Danesi V, Tozzi G. Digital volume correlation can be used to estimate local strains in natural and augmented vertebrae: an organ-level study. J Biomech. December 8, 2016;49(16):3882-3890.

Year

Entry

2004

Barrett JF, Keat N. Artifacts in CT: recognition and avoidance. RadioGraphics. November–December 2004;24(6):1679-1691.

2022

Buss DJ, Kröger R, McKee MD, Reznikov N. Hierarchical organization of bone in three dimensions: a twist of twists. J Struct Biol X. 2022;6:100057.

2001

Fajardo RJ, Müller R. Three‐dimensional analysis of nonhuman primate trabecular architecture using micro‐computed tomography. Am J Phys Anthropol. 2001;115(4):327-336.

2010

Cristofolini L, Schileo E, Juszczyk M, Taddei F, Martelli S, Viceconti M. Mechanical testing of bones: the positive synergy of finite–element models and in vitro experiments. Philos Trans R Soc A-Math Phys Eng Sci. June 13, 2010;368(1920):2725-2763.

2019

Kusins J, Knowles N, Ryan M, Dall’Ara E, Ferreira L. Performance of QCT-derived scapula finite element models in predicting local displacements using digital volume correlation. J Mech Behav Biomed Mater. September 2019;97:339-345.

1999

Bay BK, Smith TS, Fyhrie DP, Saad M. Digital volume correlation: three-dimensional strain mapping using X-ray tomography. Exp Mech. September 1999;39(3):217-226.

2015

Oftadeh R, Perez-Viloria M, Villa-Camacho JC, Vaziri A, Nazarian A. Biomechanics and mechanobiology of trabecular bone: a review. J Biomech Eng. January 2015;137(1):010802.

2019

Knowles NK, Kusins J, Faieghi M, Ryan M, Dall’Ara E, Ferreira LM. Material mapping of QCT-derived scapular models: a comparison with micro-CT loaded specimens using digital volume correlation. Ann Biomed Eng. November 2019;47(11):2188-2198.

2005

Nagaraja S, Couse TL, Guldberg RE. Trabecular bone microdamage and microstructural stresses under uniaxial compression. J Biomech. 2005;38(4):707-716.

2004

Bayraktar HH, Morgan EF, Niebur GL, Morris GE, Wong EK, Keaveny TM. Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue. J Biomech. January 2004;37(1):27-35.

2017

du Plessis A, Broeckhoven C, Guelpa A, le Roux SG. Laboratory x-ray micro-computed tomography: a user guideline for biological samples. GigaScience. June 2017;6(6):gix027.

2007

Liu L, Morgan EF. Accuracy and precision of digital volume correlation in quantifying displacements and strains in trabecular bone. J Biomech. 2007;40(15):3516-3520.

1989

Odgaard A, Hvid I, Linde F. Compressive axial strain distributions in cancellous bone specimens. J Biomech. 1989;22(8-9):829-835.

2019

Comini F, Palanca M, Cristofolini L, Dall’Ara E. Uncertainties of synchrotron microCT-based digital volume correlation bone strain measurements under simulated deformation. J Biomech. March 27, 2019;86:232-237.

2019

van Dijk NP, Wu D, Persson C, Isaksson P. A global digital volume correlation algorithm based on higher-order finite elements: implementation and evaluation. Int J Solids Struct. August 15, 2019;168:211-227.

2014

Dong P, Haupert S, Hesse B, Langer M, Gouttenoire P-J, Bousson V, Peyrin F. 3D osteocyte lacunar morphometric properties and distributions in human femoral cortical bone using synchrotron radiation micro-CT images. Bone. March 2014;60:172-185.

2006

Stauber M, Rapillard L, van Lenthe GH, Zysset P, Müller R. Importance of individual rods and plates in the assessment of bone quality and their contribution to bone stiffness. J Bone Miner Res. April 2006;21(4):586-595.

2001

Morgan EF, Keaveny TM. Dependence of yield strain of human trabecular bone on anatomic site. J Biomech. 2001;34(5):569-577.

1996

Cristofolini L, Viceconti M, Cappello A, Toni A. Mechanical validation of whole bone composite femur models. J Biomech. April 1996;29(4):525-535.

2017

Dall’Ara E, Peña-Fernández M, Palanca M, Giorgi M, Cristofolini L, Tozzi G. Precision of digital volume correlation approaches for strain analysis in bone imaged with micro-computed tomography at different dimensional levels. Front Mater. November 8, 2017;4:31.

2020

Turunen MJ, Le Cann S, Tudisco E, Lovric G, Patera A, Hall SA, Isaksson H. Sub-trabecular strain evolution in human trabecular bone. Sci Rep. 2020;10:13788.

2015

Grassi L, Isaksson H. Extracting accurate strain measurements in bone mechanics: a critical review of current methods. J Mech Behav Biomed Mater. October 2015;50:43-54.

2015

Palanca M, Tozzi G, Cristofolini L, Viceconti M, Dall'Ara E. Three-dimensional local measurements of bone strain and displacement: comparison of three digital volume correlation approaches. J Biomech Eng. July 2015;137(7):071006.

2016

Palanca M, Cristofolini L, Dall’Ara E, Curto M, Innocente F, Danesi V, Tozzi G. Digital volume correlation can be used to estimate local strains in natural and augmented vertebrae: an organ-level study. J Biomech. December 8, 2016;49(16):3882-3890.

Year	Entry
2022	Tavares C. Development of a Two-Axis Cyclic Loading Device for Mechanical Testing of Glenoid Component Fixation [Master's thesis]. University of Western Ontario; 2022.

Year

Entry

2022

Tavares C. Development of a Two-Axis Cyclic Loading Device for Mechanical Testing of Glenoid Component Fixation [Master's thesis]. University of Western Ontario; 2022.