Marrow stromal cells as stem cells for nonhematopoietic tissues

Prockop, Darwin J.

Affiliations

¹Center for Gene Therapy, Allegheny University of the Health Sciences, MCP-Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA

Abstract

Marrow stromal cells can be isolated from other cells in marrow by their tendency to adhere to tissue culture plastic. The cells have many of the characteristics of stem cells for tissues that can roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts. Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy.

Links

DOI: 10.1126/science.276.5309.71

PubMed: 9082988

WoS: A1997WR38600047

Cited By (29)

Year	Entry
2005	Sakaguchi Y, Sekiya I, Yagishita K, Muneta T. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum. August 2005;52(8):2521-2529.
2005	Li W-J, Tuli R, Huang X, Laquerriere P, Tuan RS. Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomaterials. September 2005;26(25):5158-5166.
2020	Omagari D, Hayatsu M, Yamamoto K, Kobayashi M, Tsukano N, Nameta M, Mikami Y. Gap junction with MLO-A5 osteoblast-like cell line induces ALP and BSP transcription of 3T3-L1 pre-adipocyte like cell line via Hspb1 while retaining adipogenic differentiation ability. Bone. December 2020;141:115596.
2023	Beaver LM, Prati M, Gilman KE, Luo T, Shay NF, Branscum AJ, Turner RT, Iwaniec UT. Diet composition influences the effect of high fat diets on bone in growing male mice. Bone. November 2023;176:116888.
2002	Kalajzic I, Kalajzic Z, Kaliterna M, Gronowicz G, Clark SH, Lichtler AC, Rowe D. Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage. J Bone Miner Res. January 2002;17(1):15-25.
2009	Tang Y, Wu X, Lei W, Pang L, Wan C, Shi Z, Zhao L, Nagy TR, Peng X, Hu J, Feng X, Van Hul W, Wan M, Cao X. TGF-β1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med. July 2009;15(7):757-765.
2002	Hunziker EB. Articular cartilage repair: basic science and clinical progress. a review of the current status and prospects. Osteoarthritis Cartilage. June 2002;10(6):432-463.
2006	Mauck RL, Yuan X, Tuan RS. Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture. Osteoarthritis Cartilage. February 2006;14(2):179-189.
2001	Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. April 2001;7(2):211-228.
2006	Miyanishi K, Trindade MCD, Lindsey DP, Beaupré GS, Carter DR, Goodman SB, Schurman DJ, Smith RL. Effects of hydrostatic pressure and transforming growth factor-β3 on adult human mesenchymal stem cell chondrogenesis in vitro. Tissue Eng. June 2006;12(6):1419-1428.
2017	Bogdanowicz DR. Designing the Stem Cell Microenvironment for Guided Connective Tissue Regeneration [PhD thesis]. Columbia University; 2017.
2012	Diekman BO. Stem Cell-Based Strategies to Study, Prevent, and Treat Cartilage Injury and Osteoarthritis [PhD thesis]. Duke University; 2012.
2014	Bruderer MS. Transcription Factor-Specific Reporter Constructs: Basis for the Functional Identification and Isolation of Subpopulations of Human Mesenchymal Stem Cells and Tool for Live Cell Approaches [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2014.
2015	Millan CA. Formation of Engineered Microtissues by Schiff Base Crosslinking [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2015.
2007	Irons HR. Bone Marrow-Derived Mesenchymal Stem Cells as an Alternate Donor Cell Source for Transplantation in Tissue-Engineered Constructs After Traumatic Brain Injury [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2007.
2009	Deutsch ER. The Use of Stem Cell Synthesized Extracellular Matrix for Bone Repair [Master's thesis]. Atlanta, GA: Georgia Institute of Technology; December 2009.
2015	Allen AB. Modulation of Stem Cell Delivery Strategy by Platelet Lysate Utilization and Cell Aggregation for Enhanced Bone Regeneration [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2015.
2008	Wang L. Tissue Engineering the TMJ Condyle Using Human Umbilical Cord Mesenchymal Stromal Cells [PhD thesis]. Lawrence, KS: University of Kansas; 2008.
2003	Chan GK. Delineation of Regulatory Factors and Mechanisms That Govern the Differentiation of Mesenchymal Cells to the Osteoblastic Lineage [PhD thesis]. McGill University; June 2003.
2017	Dwivedi G. Identification of in Situ Progenitor Cell Features Contributing to Cartilage Repair and Strategies for Cartilage Repair Augmentation [PhD thesis]. École polytechnique de Montréal; April 2017.
2007	Malone AMD. Mechanotransduction Mechanisms in Bone Cells [PhD thesis]. Stanford University; August 2007.
2014	Pagnotti GM. Low Intensity Vibrations Mitigate Cancer-Induced Bone Loss With Indications of Reduced Tumor Progression [PhD thesis]. Stony Brook, NY: Stony Brook University; August 2014.
2004	Rea Fureigh KL. Development and Characterization of a Three-Dimensional Model of Brain Tissue With Application for the Study of Parkinson's Disease [PhD thesis]. Tulane University; 2004.
2013	Mostafa NAHZ. Tissue Engineering Therapies for Cleft Palate Reconstruction [PhD thesis]. Edmonton, AB: University of Alberta; 2013.
2006	Jadin KD. Mechanisms of Growth of Articular Cartilage: Cell Organization and Fates [PhD thesis]. San Diego (UCSD), University of California; 2006.
2006	Staples AK. Mechanical and Biological Mechanisms of Regulating Human Mesenchymal Stem Cell Differentiation [PhD thesis]. San Francisco, University of California; 2006.
2009	Kim AJ. In Situ Regeneration of the Nucleus Pulposus [PhD thesis]. San Francisco, University of California; 2009.
2010	Huang AH. Enhancing Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2011	Erickson IE. Optimization and Translation of MSC-Based Hyaluronic Acid Hydrogels for Cartilage Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2011.