No complete crash test dummy has been compared with respect to human responses in motorcycleto-car crash loading. Following previous testing, post-mortem human subject (PMHS) results provided a new target for a human rider in a single full-scale motorcycle-to-car crash scenario. The same crash configuration was recreated with the Powered Two-Wheeler (PTW) Dummy as rider, i.e. a KTM 390 Duke colliding 30 degrees forward of perpendicular into a stationary Honda Accord saloon with the motorcycle travelling at 50 km/h. The dummy test had broadly similar interactions between motorcycle and car, rider and motorcycle and, to some extent, the rider and car. However, differences between PMHS and Dummy (in peak acceleration and duration of loading) occurred in the retention of the pelvis by the fuel tank. In the dummy, subsequent large tensile lumbar spine forces led to an obvious kinematic difference, whereby the head of the dummy hit the roof-rail of the car, whilst the head of each of the three PMHS passed over the top. The PTW Dummy may be a robust tool for use in motorcycle-to-car crash testing, but use of the PTW Dummy in common crash configurations, like this front-ofthe-motorcycle into the side-of-the-car case, could underestimate the risk of thoracic injury.