Image-based musculoskeletal modeling:​ applications, advances, and future opportunities

Blemker, Silvia S.; Asakawa, Deanna S.; Gold, Garry E.; Delp, Scott L.

Affiliations

¹Department of Mechanical & Aerospace Engineering, University of Virginia, Charlottesville, Virginia, USA

²Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA

³Department of Bioengineering, Stanford University, Stanford, California, USA

⁴Department of Radiology, Stanford University, Stanford, California, USA

⁵Department of Mechanical Engineering, Stanford University, Stanford, California, USA

Abstract and keywords

Computer models of the musculoskeletal system are broadly used to study the mechanisms of musculoskeletal disorders and to simulate surgical treatments. Musculoskeletal models have historically been created based on data derived in anatomical and biomechanical studies of cadaveric specimens. MRI offers an abundance of novel methods for acquisition of data from living subjects and is revolutionizing the field of musculoskeletal modeling. The need to create accurate, individualized models of the musculoskeletal system is driving advances in MRI techniques including static imaging, dynamic imaging, diffusion imaging, body imaging, pulse-sequence design, and coil design. These techniques apply to imaging musculoskeletal anatomy, muscle architecture, joint motions, muscle moment arms, and muscle tissue deformations. Further advancements in image-based musculoskeletal modeling will expand the accuracy and utility of models used to study musculoskeletal and neuromuscular impairments.

Keywords: skeletal muscle; biomechanics; human movement; muscle architecture; magnetic resonance imaging; dynamic imaging; musculoskeletal modeling

Links

DOI: 10.1002/jmri.20805

PubMed: 17260405

WoS: 000244133000020

History

Received: 2006-05-04

Accepted: 2006-09-13

Cited Works (21)

Year	Entry
1998	Andriacchi TP, Alexander EJ, Toney MK, Dyrby C, Sum J. A point cluster method for in vivo motion analysis: applied to a study of knee kinematics. J Biomech Eng. December 1998;120(6):743-749.
2001	Piazza SJ, Delp SL. Three-dimensional dynamic simulation of total knee replacement motion during a step-up task. J Biomech Eng. December 2001;123(6):599-606.
1996	Piazza SJ, Delp SL. The influence of muscles on knee flexion during the swing phase of gait. J Biomech. June 1996;29(6):723-733.
2005	Blemker SS, Delp SL. Three-dimensional representation of complex muscle architectures and geometries. Ann Biomed Eng. May 2005;33(5):661-673.
2000	Arnold AS, Salinas S, Hakawa DJ, Delp SL. Accuracy of muscle moment arms estimated from MRI-based musculoskeletal models of the lower extremity. Comput Aided Surg. 2000;5(2):108-119.
2003	Anderson FC, Pandy MG. Individual muscle contributions to support in normal walking. Gait Post. April 2003;17(2):159-169.
2002	Pappas GP, Asakawa DS, Delp SL, Zajac FE, Drace JE. Nonuniform shortening in the biceps brachii during elbow flexion. J Appl Physiol. June 2002;92(6):2381-2389.
1984	An KN, Takahashi K, Harrigan TP, Chao EY. Determination of muscle orientations and moment arms. J Biomech Eng. August 1984;106(3):280-282.
2004	Fleming BC, Beynnon BD. In vivo measurement of ligament/tendon strains and forces: a review. Ann Biomed Eng. 2004;32(3):318-328.
2003	McLean SG, Su A, van den Bogert AJ. Development and validation of a 3-D model to predict knee joint loading during dynamic movement. J Biomech. December 2003;125(6):864-874.
2000	Murray WM, Buchanan TS, Delp SL. The isometric functional capacity of muscles that cross the elbow. J Biomech. August 2000;33(8):943-952.
1990	Alexander RM, Ker RF. The architecture of leg muscles. In: Winters JM, Woo SL-Y, eds. Multiple Muscle Systems: Biomechanics and Movement Organization. New York, NY: Springer-Verlag; 1990:568-577.
1995	Murray WM, Delp SL, Buchanan TS. Variation of muscle moment arms with elbow and forearm position. J Biomech. May 1995;28(5):513-525.
1998	Sheehan FT, Zajac FE, Drace JE. Using cine phase contrast magnetic resonance imaging to non-invasively study in vivo knee dynamics. J Biomech. January 1998;31(1):21-26.
1990	Rugg SG, Gregor RJ, Mandelbaum BR, Chiu L. In vivo moment arm calculations at the ankle using magnetic resonance imaging (MRI). J Biomech. 1990;23(5):495-501.
2005	Blemker SS, Pinsky PM, Delp SL. A 3D model of muscle reveals the causes of nonuniform strains in the biceps brachii. J Biomech. April 1, 2005;38(4):657-665.
1992	Besl PJ, McKay ND. A method for registration of 3-D shapes. IEEE Trans Pattern Anal Mach Intell. February 1992;14(2):239-256.
1990	Delp SL, Loan JP, Hoy MG, Zajac FE, Topp EL, Rosen JM. An interactive graphics-based model of the lower extremity to study orthopaedic surgical procedures. IEEE Trans Biomed Eng. 1990;37(8):757-767.
1994	Delp SL, Ringwelski DA, Carroll NC. Transfer of the rectus femoris: effects of transfer site on moment arms about the knee and hip. J Biomech. October 1994;27(10):1201-1211.
1989	Zajac FE. Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. Crit Rev Biomed Eng. 1989;17(4):359-411.
2006	Higginson JS, Zajac FE, Neptune RR, Kautz SA, Delp SL. Muscle contributions to support during gait in an individual with post-stroke hemiparesis. J Biomech. 2006;39(10):1769-1777.

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2008	Winby CR, Lloyd DG, Kirk TB. Evaluation of different analytical methods for subject-specific scaling of musculotendon parameters. J Biomech. 2008;41(8):1682-1688.
2011	Correa TA, Baker R, Kerr Graham H, Pandy MG. Accuracy of generic musculoskeletal models in predicting the functional roles of muscles in human gait. J Biomech. July 28, 2011;44(11):2096-2105.
2015	Carbone V, Fluit R, Pellikaan P, van der Krogt MM, Janssen D, Damsgaard M, Vigneron L, Feilkas T, Koopman HFJM, Verdonschot N. TLEM 2.0: a comprehensive musculoskeletal geometry dataset for subject-specific modeling of lower extremity. J Biomech. March 18, 2015;48(5):734-741.
2016	Modenese L, Ceseracciu E, Reggiani M, Lloyd DG. Estimation of musculotendon parameters for scaled and subject specific musculoskeletal models using an optimization technique. J Biomech. January 25, 2016;49(2):141-148.
2023	Wakeling JM, Febrer-Nafría M, De Groote F. A review of the efforts to develop muscle and musculoskeletal models for biomechanics in the last 50 years. J Biomech. June 2023;155:111657.
2023	Blemker SS. In vivo imaging of skeletal muscle form and function: 50 years of insight. J Biomech. September 2023;158:111745.
2023	Persad LS, Binder-Markey BI, Shin AY, Lieber RL, Kaufman KR. American Society of Biomechanics Journal of Biomechanics Award 2022: computer models do not accurately predict human muscle passive muscle force and fiber length: evaluating subject-specific modeling impact on musculoskeletal model predictions. J Biomech. October 2023;159:111798.
2015	Hicks JL, Uchida TK, Seth A, Rajagopal A, Delp SL. Is my model good enough? best practices for verification and validation of musculoskeletal models and simulations of movement. J Biomech Eng. February 2015;137(2):020905.
2016	Ha CWS. A Subject-Specific Computational Model to Investigate an Ankle Inversion Ligamentous Sprain Injury and Evaluate the Intelligent Anti-Sprain System [PhD thesis]. The Chinese University of Hong Kong; October 2016.
2016	Navacchia A. Multiscale Musculoskeletal Modeling of the Lower Limb to Perform Personalized Simulations of Movement [PhD thesis]. University of Denver; November 2016.
2018	Hume DR. Translating Data from the Laboratory Into Simulation: A Computational Framework for Subject-Specific Finite Element Musculoskeletal Simulation [PhD thesis]. University of Denver; August 2018.
2013	Johnson JE. Effects of Surgical Repair or Reconstruction on Radiocarpal Mechanics from Wrists With Scapholunate Ligament Injury [PhD thesis]. Lawrence, KS: University of Kansas; 2013.
2013	Thompson JA. The Effect of Quadriceps Weakness on Lower Extremity Muscle Function During Gait [PhD thesis]. The Ohio State University; 2013.
2012	Waanders D. Micro and Macro Level Damage Mechanics of the Cement-Bone Interface in Total Hip Arthroplasty [PhD thesis]. Radboud University; 2012.
2008	Draper CE. Patellofemoral Joint Geometry and Motion Measured Using Magnetic Resonance Imaging [PhD thesis]. Stanford University; 2008.
2011	Webb JD. Contributions of the Deltoid and Rotator Cuff to Shoulder Mobility and Stability: A 3D Finite Element Analysis [PhD thesis]. Stanford University; August 2011.
2012	Arnold EM. Computer Modeling of Human Lower Limb Muscles to Study How Muscle Fiber Lengths and Velocities Affect Muscle Force Generation During Walking and Running [PhD thesis]. Stanford University; July 2012.
2009	Xiao M. Computer Simulation of Human Walking: Model Sensitivity and Application to Stroke Gait [PhD thesis]. University of Delaware; 2009.
2014	Ramsay JW. Muscle Morphological Changes, Compensatory Strategies and the Use of Predictive Simulations to Direct the Rehabilitation of Individuals Post-Stroke [PhD thesis]. University of Delaware; 2014.
2014	Tan K. Characterising the Viscoelasticity of Soft Biological Tissues Under Large Deformation [PhD thesis]. University of New South Wales; March 2014.
2012	Kurse MU. Inference of Computational Models of Tendon Networks Via Sparse Experimentation [PhD thesis]. University of Southern California (USC); August 2012.
2013	Fiorentino N. Insights Into Acute Muscle Strain Injury Obtained With in Vivo Imaging and Finite Element Modeling [PhD thesis]. Charlottesville, VA: University of Virginia; May 2013.
2014	Handsfield GG. MRI and Computational Modeling of in Vivo Muscle-Tendon Architecture and Function [PhD thesis]. Charlottesville, VA: University of Virginia; December 2014.
2018	Terrell E. In Vivo Determination of the Physiological and Functional Properties of Muscle Using Multiscale Measurements of Muscle Architecture [Master's thesis]. Charlottesville, VA: University of Virginia; May 2018.
2023	Kuska E. In Silico Techniques to Improve Understanding of Gait in Cerebral Palsy [PhD thesis]. University of Washington; 2023.
2019	Smith CR. Simulating the Effects of Anterior Cruciate Ligament Injury and Treatment on Cartilage Loading During Walking [PhD thesis]. University of Wisconsin – Madison; 2019.
2012	Suderman BL. The Effect of Curvature on Neck Muscle Moment Arms [PhD thesis]. Pullman, WA: Washington State University; August 2012.
2021	Song K. Subject-Specific Musculoskeletal Modeling of Hip Dysplasia Biomechanics [PhD thesis]. St. Louis, MO: Washington University in St. Louis; May 2021.