Both the Hill and the Huxley muscle models had already been described by the time the International Society of Biomechanics was founded 50 years ago, but had seen little use before the 1970s due to the lack of computing. As computers and computational methods became available in the 1970s, the field of musculoskeletal modeling developed and Hill type muscle models were adopted by biomechanists due to their relative computational simplicity as compared to Huxley type muscle models. Muscle forces computed by Hill type muscle models provide good agreement in conditions similar to the initial studies, i.e. for small muscles contracting under steady and controlled conditions. However, more recent validation studies have identified that Hill type muscle models are least accurate for natural in vivo locomotor behaviours at submaximal activations, fast speeds and for larger muscles, and thus need to be improved for their use in understanding human movements. Developments in muscle modelling have tackled these shortcomings. However, over the last 50 years musculoskeletal simulations have been largely based on traditional Hill type muscle models or even simplifications of this model that neglected the interaction of the muscle with a compliant tendon. The introduction of direct collocation in musculoskeletal simulations about 15 years ago along with further improvements in computational power and numerical methods enabled the use of more complex muscle models in simulations of whole-body movement. Whereas Hill type models are still the norm, we may finally be ready to adopt more complex muscle models into musculoskeletal simulations of human movement.