Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls

wbldb

Roos, Harald¹; Laurén, Mårten¹; Adalberth, Torsten¹; Roos, Ewa M.¹; Jonsson, Kjell¹; Lohmander, L. Stefan¹

Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls

Arthritis Rheum. 1998;41(4):687-693

©1998 American College of Rheumatology

Affiliations

¹Lund University Hospital, Lund, Sweden
Abstract

Objecive: To study the long-term outcome of surgical removal of a meniscus in the knee with regard to radiographic signs of osteoarthritis (OA).

Methods: Of the 123 patients who underwent an open meniscectomy due to an isolated meniscus tear in 1973 at Lund University Hospital, 107 were followed up 21 years later by clinical examination and by review of knee radiographs obtained with weight bearing. Seventy-nine of the 107 patients were men, and the mean age of the total study group at examination was 55 years (range 35-77). Sixty-eight sex- and age-matched individuals with healthy knees served as controls.

Results: Mild radiographic changes were found in 76 (71%) of the knees, while more advanced changes, comparable with a Kellgren-Lawrence grade of 2 or higher, were seen in 51 (48%). The corresponding prevalence values in the control group were 12 (18%) and 5 (7%), respectively. The relative risk for the presence of the more advanced radiographic changes representing definite radiographic tibiofemoral OA was 14.0 (95% confidence interval 3.5-121.2), using age- and sex-matched pairs for comparison. No correlation with sex, localization to compartment, type of meniscus tear, or work load was found. Knee symptoms were reported twice as often in the study group as in the controls.

Conclusion: Surgical removal of a meniscus following knee injury represents a significant risk factor for radiographic tibiofemoral OA, with a relative risk of 14.0 after 21 years.
Links

DOI: 10.1002/1529-0131(199804)41:4<687::AID-ART16>3.0.CO;2-2

PubMed: 9550478

WoS: 000072972800015
History

Received: 1997-08-05

Accepted: 1997-11-26

Cited Works (3)

Year	Entry
1948	Fairbank TJ. Knee joint changes after meniscectomy. J Bone Joint Surg. 1948;30B(4):664-670.
1957	Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. December 1957;16(4):494-502.
1995	Roos H, Adalberth T, Dahlberg L, Lohmander LS. Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. Osteoarthritis Cartilage. December 1995;3(3):261-267.

Cited By (43)

Year	Entry
2000	Gelber AC, Hochberg MC, Mead LA, Wang N-Y, Wigley FM, Klag MJ. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med. September 5, 2000;133(5):321-328.
2004	von Porat A, Roos EM, Roos H. High prevalence of osteoarthritis 14 years after an anterior cruciate ligament tear in male soccer players: a study of radiographic and patient relevant outcomes. Ann Rheum Dis. March 2004;63(3):269-273.
2004	Lohmander LS, Östenberg A, Englund M, Roos H. High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. Arthritis Rheum. October 2004;50(10):3145-3152.
2023	Heiss R, Laredo J-D, Wirth W, Jansen MP, Marijnissen AC, Lafeber F, Lalande A, Weinans HH, Blanco FJ, Berenbaum F, Kloppenburg M, Haugen IK, Engelke K, Roemer FW. Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort: association of bone mineral density with radiographic disease severity, meniscal coverage and meniscal extrusion. Bone. March 2023;168:116673.
2005	Roos EM. Joint injury causes knee osteoarthritis in young adults. Curr Opin Rhuematol. March 2005;17(2):195-200.
2003	Wilson W, van Rietbergen B, van Donkelaar CC, Huiskes R. Pathways of load-induced cartilage damage causing cartilage degeneration in the knee after meniscectomy. J Biomech. June 2003;36(6):845-851.
2004	Vanderploeg EJ, Imler SM, Brodkin KR, Garcı́a AJ, Levenston ME. Oscillatory tension differentially modulates matrix metabolism and cytoskeletal organization in chondrocytes and fibrochondrocytes. J Biomech. December 2004;37(12):1941-1952.
2006	Shelburne KB, Torry MR, Pandy MG. Contributions of muscles, ligaments, and the ground-reaction force to tibiofemoral joint loading during normal gait. J Orthop Res. October 2006;24(10):1983-1990.
2011	Anderson DD, Chubinskaya S, Guilak F, Martin JA, Oegema TR, Olson SA, Buckwalter JA. Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J Orthop Res. June 2011;29(6):802-809.
2010	Bowers ME. Partial Meniscectomy and Osteoarthritis: Evaluation With Quantitative Magnetic Resonance Imaging [PhD thesis]. Brown University; May 2010.
2012	Galley NK. Alterations in Tribologic Behavior of Cartilage During Tissue Degeneration and Repair [PhD thesis]. Ithaca, NY: Cornell University; January 2012.
2018	Li Q. Role of Meniscus Micromechanics in Joint Function and Osteoarthritis [PhD thesis]. Drexel University; December 2018.
2000	LeRoux MA. Altered Mechanics of the Meniscus With a Healing Tear: Experimental Testing and Biphasic Finite Element Analysis [PhD thesis]. Duke University; 2000.
2007	Upton ML. Theoretical Predictions and Experimental Measurements of the Micromechanical Environment of Meniscus Cells [PhD thesis]. Duke University; 2007.
2016	Glass KA. Combined Gene Therapy and Functional Tissue Engineering for the Treatment of Osteoarthritis [PhD thesis]. Duke University; 2016.
2022	Andress B. The Meniscus Cell Phenotype: Effects of Physical, Mechanical, and Inflammatory Environments [PhD thesis]. Duke University; 2022.
2005	Imler SM. In Vitro Modulation of Meniscus Biosynthesis: A Basis for Understanding Cellular Response to Physiologically Relevant Stimuli [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2005.
2006	Vanderploeg EJ. Mechanotransduction in Engineered Cartilaginous Tissues: In Vitro Oscillatory Tensile Loading [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2006.
2007	Wilson CG. Mechanisms and Functional Implications of Aggrecan Catabolism in Cartilage and Meniscal Fibrocartilage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2007.
2014	Thote T. Evaluation of Therapeutics Strategies for Osteoarthritis Using Contrast Based CT Imaging Atlanta, GA: Georgia Institute of Technology; August 2014.
2006	Stevens AL. Mechanical Injury and Inflammatory Cytokines Affect Cartilage Integrity and Tissue Homeostasis: A Mass Spectrometric Analysis of Proteins With Relevance to Arthritis [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2006.
2008	Wheeler CA. Cartilage Response to in Vitro Models of Injury in Combination With Growth Factor and Antioxidant Treatments [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; February 2008.
2016	Young WT. Cartilage Stress Relaxation Induced by Intra-Tissue Transport of Cationic Nanoparticles: Implications for Post-Traumatic Osteoarthritis Drug Delivery [Master's thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2016.
2010	Killian ML. The Influence of Traumatic Impaction and Pathological Loading on Knee Menisci [PhD thesis]. Houghton, MI: Michigan Technological University; 2010.
2017	Nordberg RC. Translating Human Adipose Stem Cells for Musculoskeletal Applications: A Tissue Engineering, Mechanistic, and Electrical Cell-Substrate Impedance Spectroscopy Approach [PhD thesis]. North Carolina State University; 2017.
2014	Lathrop RL. Investigation of Measurable Biomechanical Factors That May Influence Articular Cartilage Degeneration in the Knee [PhD thesis]. The Ohio State University; 2014.
2014	Marsh CA. The Development and Application of an Arthrokinematic Biomarker for the Early Detection of Osteoarthritis [PhD thesis]. University of Pittsburgh; 2014.
2008	Shirazi Aghjari R. Computational Biomechanics of the Human Knee Joint: Role of Collagen Fibrils Networks [PhD thesis]. École polytechnique de Montréal; December 2008.
2019	Al-Maruf DSA. Effects of Anti-Angiogenic Factors in Two Different Models of Osteoarthritis [PhD thesis]. Queensland University of Technology; 2019.
2008	Erhart JC. Efficacy of a Variable -Stiffness Footwear Intervention for Treatment of Medial Compartment Knee Osteoarthritis [PhD thesis]. Stanford University; November 2008.
2009	Haemer JM. Mechanical Etiology of Osteoarthritis After Meniscectomy [PhD thesis]. Stanford University; June 2009.
2009	Song Y. Fibro-Cartilaginous Structures about the Knee and Hip: Relation to Development of Osteoarthritis [PhD thesis]. Stanford University; September 2009.
2010	Netravali NA. Meniscal Damage, Partial Medial Meniscectomy, and the Development of Osteoarthritis [PhD thesis]. Stanford University; November 2010.
2013	Son M-S. Defining and Detecting Meniscal Heterogeneityc: Implications on Treatment and Diagnosis of Osteoarthritis [PhD thesis]. Stanford University; March 2013.
2016	Edd SN. The Development of Post-Traumatic and Idiopathic Osteoarthritis of the Knee [PhD thesis]. Stanford University; May 2016.
2013	Andrews S. Meniscus Structure and Function [PhD thesis]. Calgary, AB: University of Calgary; January 2013.
2019	Kroker AM. The Progression of Bone Microarchitecture Changes Following an Acute Knee Injury in Young Adults [PhD thesis]. Calgary, AB: University of Calgary; March 2019.
2019	Rios JL. Exercise and Dietary Interventions in a Rat Model of Metabolic Knee Osteoarthritis [PhD thesis]. Calgary, AB: University of Calgary; September 2019.
2019	Shtil M. Longitudinal Assessment of Mechanical Strength of Trabecular Bone Underlying Bone Marrow Lesions Following Acute Anterior Cruciate Ligament Injuries [Master's thesis]. Calgary, AB: University of Calgary; June 2019.
2015	Baek J. Electrospinning of Nanofibrous Scaffolds for Meniscal Tissue Engineering [PhD thesis]. San Diego (UCSD), University of California; 2015.
2017	Lakes EH. Advancing Methods for Multiscale Mechanics in Orthopaedic Research [PhD thesis]. University of Florida; December 2017.
2010	Baker BM. Meniscus Tissue Engineering With Nanofibrous Scaffolds [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2017	Mohanraj B. High Throughput and Mechano-Active Platforms to Promote Cartilage Regeneration and Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2017.