Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering

Rezwan, K.; Chen, Q. Z.; Blaker, J. J.; Boccaccini, Aldo Roberto

Affiliations

¹Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK

²Centre for Tissue Engineering and Regenerative Medicine, Imperial College London, London SW7 2AZ, UK

Abstract

Biodegradable polymers and bioactive ceramics are being combined in a variety of composite materials for tissue engineering scaffolds. Materials and fabrication routes for three-dimensional (3D) scaffolds with interconnected high porosities suitable for bone tissue engineering are reviewed. Different polymer and ceramic compositions applied and their impact on biodegradability and bioactivity of the scaffolds are discussed, including in vitro and in vivo assessments. The mechanical properties of today's available porous scaffolds are analyzed in detail, revealing insufficient elastic stiffness and compressive strength compared to human bone. Further challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies. Stem cell incorporation into scaffolds as a future trend is addressed shortly, highlighting the immense potential for creating next-generation synthetic/living composite biomaterials that feature high adaptiveness to the biological environment.

Links

DOI: 10.1016/j.biomaterials.2006.01.039

PubMed: 16504284

WoS: 000236783000010

History

Received: 2005-12-6

Accepted: 2006-01-31

Online: 2006-02-28

Cited Works (6)

Year	Entry
1985	Gibson LJ. The mechanical behaviour of cancellous bone. J Biomech. 1985;18(5):317-328.
2005	Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials. September 2005;26(27):5474-5491.
1998	Zioupos P, Currey JD. Changes in the stiffness, strength, and toughness of human cortical bone with age. Bone. January 1998;22(1):57-66.
2001	Yeni YN, Fyhrie DP. Finite element calculated uniaxial apparent stiffness is a consistent predictor of uniaxial apparent strength in human vertebral cancellous bone tested with different boundary conditions. J Biomech. December 2001;34(12):1649-1654.
2001	Yang S, Leong K-F, Du Z, Chua C-K. The design of scaffolds for use in tissue engineering, I: traditional factors. Tissue Eng. December 2001;7(6):679-689.
2003	Taboas JM, Maddox RD, Krebsbach PH, Hollister SJ. Indirect solid free form fab.rication of local and global porous, biomimetic and composite 3d polymer-ceramic scaffolds. Biomaterials. January 2003;24(1):181-194.

Cited By (23)

Year	Entry
2020	Li T, Ma B, Xue J, Zhai D, Zhao P, Chang J, Wu C. Bioinspired biomaterials with a brick‐and‐mortar microstructure combining mechanical and biological performance. Adv Healthc Mater. February 2020;9(4):1901211.
2020	Amini M, Reisinger A, Pahr DH. Influence of processing parameters on mechanical properties of a 3D-printed trabecular bone microstructure. J Biomed Mater Res. January 2020;B108(1):38-47.
2009	Al-Munajjed AA, O’Brien FJ. Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair. J Mech Behav Biomed Mater. April 2009;2(2):138-146.
2023	Colon RR, Nayak VV, Parente PEL, Leucht P, Tovar N, Lin CC, Rezzadeh K, Hacquebord JH, Coelho PG, Witek L. The presence of 3D printing in orthopedics: a clinical and material review. J Orthop Res. March 2023;41(3):601-613.
2009	Wojtowicz AM. Genetically-Engineered Bone Marrow Stromal Cells and Collagen Mimetic Scaffold Modification for Healing Critically-Sized Bone Defects [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2009.
2011	Boerckel JD. Mechanical Regulation of Bone Regeneration and Vascular Growth in Vivo [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2011.
2019	Karadaş Ö. Biochemical and Mechanical Cues for Osteogenic Induction of Stem Cells on Paper Based Scaffolds [PhD thesis]. Izmir Institute of Technology; December 2019.
2008	Wang L. Tissue Engineering the TMJ Condyle Using Human Umbilical Cord Mesenchymal Stromal Cells [PhD thesis]. Lawrence, KS: University of Kansas; 2008.
2010	Haslauer CM. Design and Validation of Three-Dimensional Scaffolds for Bone Tissue Engineering Applications Using Human Adipose-Derived Adult Stem Cells [PhD thesis]. North Carolina State University; 2010.
2015	Tuin SA. Enhanced Mass Transport Nonwovens as Industrial Scale Tissue Engineering Scaffolds Using Human Adipose Derived Stem Cells [PhD thesis]. North Carolina State University; 2015.
2008	Converse GL. Processing and Properties of Hydroxyapaptite Whisker Reinforced Polyaryletherketones for Orthopaedic Applications [PhD thesis]. University of Notre Dame; April 2008.
2012	Conrad TL. Characterization of Hydroxyapatite Whisker Reinforced Composites and Scaffolds for Mechanical and Biological Function in Orthopaedic and Spinal Implants [PhD thesis]. University of Notre Dame; December 2012.
2012	Kane RJ. Hydroxyapatite-Reinforced Collagen Tissue Engineering Scaffolds [PhD thesis]. University of Notre Dame; January 2012.
2021	Olivier C. Evaluation of the in Vitro Biocompatibility of Cortical Bone Matrix [Master's thesis]. Potchefstroom, South Africa: North-West University; November 2021.
2015	Bartnikowski M. Design and Characterisation of Scaffolds for Osteochondral Regeneration [PhD thesis]. Queensland University of Technology; December 2015.
2019	Forrestal DP. Flow Control in Perfusion Bioreactors for Improved Cell Culture Within Porous Tissue Scaffolds [PhD thesis]. Queensland University of Technology; 2019.
2007	Rossello RA. Cell-to-Cell Communication as a Strategy to Regenerate Three-Dimensional Tissue [PhD thesis]. University of Michigan; 2007.
2011	Saito E. Designed Biodegradable and Osteoconductive Porous Scaffolds for Human Trabecular Bone [PhD thesis]. University of Michigan; 2011.
2007	Wu Y-L. Interaction of Bone Cells With Biomimetic Hydroxyapatite Gelatin Nanocomposites Towards Developing Bone Tissue Engineering [PhD thesis]. University of Minnesota; December 2007.
2009	Ue JW-T. The Effect of Sodium Doping on Calcium Polyphosphate [Master's thesis]. University of Toronto; 2009.
2014	Peng P. Metallurgical Issues in Low-Temperature Joining of Silver Nanowires [PhD thesis]. University of Waterloo; 2014.
2011	Baker KC. Supercritical Carbon Dioxide-Processed Resorbable Polymer Nanocomposites for Bone Graft Substitute Applications [PhD thesis]. Detroit, MI: Wayne State University; August 2011.
2011	Vivanco Morales JF. Investigation of Fabrication and Environmental Effects on Bioceramic Bone Scaffolds [PhD thesis]. University of Wisconsin – Madison; 2011.