Orientation of collagen in human tibial and fibular shaft and possible correlation with mechanical properties

Carando, S.<sup>1</sup>; Portigliatti Barbos, M.<sup>1</sup>; Ascenzi, A.<sup>2</sup>; Boyde, A.<sup>3</sup>

Affiliations

¹Orthopaedic Department, University of Turin, Turin Italy

²Department of Human Biopathology, Section of Morbid Anatomy, La Sapienza University, Rome, Italy

³Department of Anatomy and Development Biology, University College London, London, England

Abstract and keywords

The pattern of collagen orientation in two human tibiae and fibulae was studied. Serial 100 μm plane parallel cross-sections at 1 cm intervals at the same level in tibia and fibula were cut using an annular blade saw. Distribution of transversely oriented collagen was mapped using circularly polarized light and an image analyzing computer. In both the tibia and fibula the pattern of collagen orientation is characteristic, which may be related to the distribution of the bending forces normally operative in these bones.

Keywords: Tibia; Fibula; Collagen orientation; Image analysis; Biomechanics

Links

DOI: 10.1016/8756-3282(89)90012-4

PubMed: 2765311

WoS: A1989AH99800011

History

Received: 1988-03-4

Revised: 1988-12-05

Accepted: 1988-12-15

Online: 2004-04-26

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Cited By (17)

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1993	Riggs CM, Lanyon LE, Boyde A. Functional associations between collagen fibre orientation and locomotor strain direction in cortical bone of the equine radius. Anat Embryol. March 1993;187(3):231-238.
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1992	Pidaparti RMV, Burr DB. Collagen fiber orientation and geometry effects on the mechanical properties of secondary osteons. J Biomech. August 1992;25(8):869-880.
2021	Maghami E, Josephson TO, Moore JP, Rezaee T, Freeman TA, Karim L, Najafi AR. Fracture behavior of human cortical bone: role of advanced glycation end-products and microstructural features. J Biomech. August 26, 2021;125:110600.
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2023	Maghami E. Fracture Micromechanics Analyses of Hard Tissues: Study of Increased Glycation Through Diabetes and Age-Related Changes [PhD thesis]. Drexel University; January 2023.
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2010	Beckstrom AB. Histologic and Geometric Data Challenge the Assumption of Habitual Superior-Inferior (tension-Compression) Bending Across the Chimpanzee Proximal Femur [Master's thesis]. University of Utah; August 2010.
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2014	Makowski AJ. Evaluation of Raman Spectroscopy for Fracture Resistance Assessment [PhD thesis]. Nashville, TN: Vanderbilt University; December 2014.
1998	Yeni YN. Fracture Mechanics of Human Cortical Bone: The Relationship of Geometry, Microstructure and Composition With the Fracture of the Tibia, Femoral Shaft and the Femoral Neck [PhD thesis]. Morgantown, WV: West Virginia University; 1998.