Orientation of collagen in human tibial and fibular shaft and possible correlation with mechanical properties

Carando, S.; Portigliatti Barbos, M.; Ascenzi, A.; Boyde, A.

Affiliations

¹Orthopaedic Department, University of Turin, Turin Italy

²Department of Human Biopathology, Section of Morbid Anatomy, La Sapienza University, Rome, Italy

³Department of Anatomy and Development Biology, University College London, London, England

Abstract and keywords

The pattern of collagen orientation in two human tibiae and fibulae was studied. Serial 100 μm plane parallel cross-sections at 1 cm intervals at the same level in tibia and fibula were cut using an annular blade saw. Distribution of transversely oriented collagen was mapped using circularly polarized light and an image analyzing computer. In both the tibia and fibula the pattern of collagen orientation is characteristic, which may be related to the distribution of the bending forces normally operative in these bones.

Keywords: Tibia; Fibula; Collagen orientation; Image analysis; Biomechanics

Links

DOI: 10.1016/8756-3282(89)90012-4

PubMed: 2765311

WoS: A1989AH99800011

History

Received: 1988-03-4

Revised: 1988-12-05

Accepted: 1988-12-15

Online: 2004-04-26

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Cited By (17)

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1993	Riggs CM, Lanyon LE, Boyde A. Functional associations between collagen fibre orientation and locomotor strain direction in cortical bone of the equine radius. Anat Embryol. March 1993;187(3):231-238.
1990	Boyde A, Riggs CM. The quantitative study of the orientation of collagen in compact bone slices. Bone. 1990;11(1):35-39.
1997	Yeni YN, Brown CU, Wang Z, Norman TL. The influence of bone morphology on fracture toughness of the human femur and tibia. Bone. November 1997;21(4):453-459.
2007	Kazanci M, Wagner HD, Manjubala NI, Gupta HS, Paschalis E, Roschger P, Fratzl P. Raman imaging of two orthogonal planes within cortical bone. Bone. September 2007;41(3):456-461.
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1999	Rinnerthaler S, Roschger P, Jakob HF, Nader A, Klaushofer K, Fratzl P. Scanning small angle X-ray scattering analysis of human bone sections. Calcif Tiss Int. May 1999;64(5):422-429.
1992	Pidaparti RMV, Burr DB. Collagen fiber orientation and geometry effects on the mechanical properties of secondary osteons. J Biomech. August 1992;25(8):869-880.
2021	Maghami E, Josephson TO, Moore JP, Rezaee T, Freeman TA, Karim L, Najafi AR. Fracture behavior of human cortical bone: role of advanced glycation end-products and microstructural features. J Biomech. August 26, 2021;125:110600.
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2023	Maghami E. Fracture Micromechanics Analyses of Hard Tissues: Study of Increased Glycation Through Diabetes and Age-Related Changes [PhD thesis]. Drexel University; January 2023.
1998	Robling AG. Histomorphometric Assessment of Mechanical Loading History from Human Skeletal Remains: The Relation Between Micromorphology and Macromorphology At the Femoral Midshaft [PhD thesis]. University of Missouri; December 1998.
2010	Beckstrom AB. Histologic and Geometric Data Challenge the Assumption of Habitual Superior-Inferior (tension-Compression) Bending Across the Chimpanzee Proximal Femur [Master's thesis]. University of Utah; August 2010.
2016	Boruah S. A Viscoelastic Model for High Strain Rate Loading of the Human Calvarium [PhD thesis]. Charlottesville, VA: University of Virginia; May 2016.
2014	Makowski AJ. Evaluation of Raman Spectroscopy for Fracture Resistance Assessment [PhD thesis]. Nashville, TN: Vanderbilt University; December 2014.
1998	Yeni YN. Fracture Mechanics of Human Cortical Bone: The Relationship of Geometry, Microstructure and Composition With the Fracture of the Tibia, Femoral Shaft and the Femoral Neck [PhD thesis]. West Virginia University; 1998.