Based on a detailed and representative French accident database, this study describes pedestrian injuries and vehicle-related risk factors in collisions between pedestrians and the front-ends of passenger cars. Injuries are described in terms of the body region injured using the Abbreviated Injury Scale (AIS). The influence vehicle-related and accident-related parameters have on the global outcome of the accidents in terms of pedestrian death and pedestrian hospitalisation or death was evaluated using a multivariate logistic regression. Risk factors such as vehicle impact speed, bonnet leading edge height, vehicle model year, impact angle and first impact location on the front-end of the vehicle were investigated. Pedestrian age was also taken into account. The results show that most injuries were sustained by the lower limbs, followed by the head, the thorax and upper limbs. Lower limbs injuries were dominated by the tibia and the fibula, followed by the pelvis and the femur. The logistic regression results show that vehicle impact speed and pedestrian age are both statistically significant and have the most influence on both outcomes, a reminder that active safety systems with the ability to reduce impact speed can have a significant impact on injury reduction.