Control of osteoblast function and regulation of bone mass

Harada, Shun-ichi; Rodan, Gideon A.

Affiliations

¹Department of Bone Biology & Osteoporosis Research, Merck Research Laboratories, West Point, Pennsylvania 19002, USA

Abstract

The skeleton is an efficient 'servo' (feedback-controlled/steady-state) system that continuously integrates signals and responses which sustain its functions of delivering calcium while maintaining strength. In many individuals, bone mass homeostasis starts failing in midlife, leading to bone loss, osteoporosis and debilitating fractures. Recent advances, spearheaded by genetic information, offer the opportunity to stop or reverse this downhill course.

Links

DOI: 10.1038/nature01660

PubMed: 12748654

WoS: 000182853100056

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