Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computed axial tomography

Layton, Mark W.; Goldstein, Steven A.; Goulet, Robert W.; Feldkamp, Lee A.; Kubinski, David J.; Bole, Giles G.

Affiliations

¹Division of Rheumatology, University of Michigan

²Current address: Olympia Arthritis and Rheumatic Disease Clinic, Olympia, Washington

³Section of Orthopaedic Surgery, University of Michigan

⁴Bioengineering Program, University of Michigan

⁵Physics Department, Ford Motor Company, Dearborn, Michigan

Abstract

Subchondral bone changes have been proposed as an early event in the pathogenesis of osteoarthritis. In this study, microscopic computed axial tomography was used to evaluate the subchondral bone structure in femoral heads from a guinea pig model of osteoarthritis. Examination of trabecular bone within the femoral head showed a highly significant increase in bone fraction in the experimental animals. This was due to the development of trabeculae that were thicker and closer together. We conclude that trabecular remodeling may be an early event in this model of osteoarthritis.

Links

DOI: 10.1002/art.1780311109

PubMed: 3190784

WoS: A1988Q973200009

History

Received: 1987-11-02

Accepted: 1988-06-09

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Cited By (26)

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2001	Fajardo RJ, Müller R. Three‐dimensional analysis of nonhuman primate trabecular architecture using micro‐computed tomography. Am J Phys Anthropol. 2001;115(4):327-336.
1993	Dedrick DK, Goldstein SA, Brandt KD, O'Connor BL, Goulet RW, Albrecht M. A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months. Arthritis Rheum. October 1993;36(10):1460-1467.
2009	Fajardo RJ, Cory E, Patel ND, Nazarian A, Laib A, Manoharan RK, Schmitz JE, DeSilva JM, MacLatchy LM, Snyder BD, Bouxsein ML. Specimen size and porosity can introduce error into μCT-based tissue mineral density measurements. Bone. 2009;44(1):176-184.
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