Changes in resorption spaces in femoral cortical bone with age

Atkinson, P. J.

Affiliations

¹Biological Research Unit, Dental School and Hospital and Department of Medcal Physics, University of Leeds

Abstract

The vascular spaces in 63 samples of femoral cortical bone at varying depth from the surface have been measured in histological sections.

The total space and number of spaces present in the cortex increases with age.

It has been shown that osteoporosis tends to spread progressively and centrifugally from the endosteum with ageing.

Links

DOI: 10.1002/path.1700890118

PubMed: 14263459

WoS: A19656206600017

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Cited By (18)

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2001	Bell KL, Loveridge N, Reeve J, Thomas CDL, Feik SA, Clement JG. Super‐osteons (remodeling clusters) in the cortex of the femoral shaft: influence of age and gender. Anat Rec. December 1, 2001;264(4):378-386.
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2015	Nirody JA, Cheng KP, Parrish RM, Burghardt AJ, Majumdar S, Link TM, Kazakia GJ. Spatial distribution of intracortical porosity varies across age and sex. Bone. June 2015;75:88-95.
2020	Andreasen CM, Bakalova LP, Brüel A, Hauge EM, Kiil BJ, Delaisse J-M, Kersh ME, Thomsen JS, Andersen TL. The generation of enlarged eroded pores upon existing intracortical canals is a major contributor to endocortical trabecularization. Bone. January 2020;130:115127.
2022	Tippen SP, Metzger CE, Swallow EA, Sacks SA, Wallace JM, Allen MR. The combination of aging and chronic kidney disease leads to an exacerbated cortical porosity phenotype. Bone. January 2022;154:116228.
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2005	Thomas CDL, Feik SA, Clement JG. Regional variation of intracortical porosity in the midshaft of the human femur: age and sex differences. J Anat. February 2005;206(2):115-125.
2006	Thomas CDL, Feik SA, Clement JG. Increase in pore area, and not pore density, is the main determinant in the development of porosity in human cortical bone. J Anat. August 2006;209(2):219-230.
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2018	Bakalova LP, Andreasen CM, Thomsen JS, Brüel A, Hauge E-M, Kiil BJ, Delaisse J-M, Andersen TL, Kersh ME. Intracortical bone mechanics are related to pore morphology and remodeling in human bone. J Bone Miner Res. December 2018;33(12):2177-2185.
2019	Livingston E. Morphological and Mechanical Analysis of the Porous Structure of Cortical Bone [Master's thesis]. University of Illinois at Urbana-Champaign; 2019.
1985	Schaffler MB. Stiffness and Fatigue of Compact Bone At Physiological Strains and Strain Rates [PhD thesis]. West Virginia University; 1985.