Subchondral bone changes in patients with early degenerative joint disease

Radin, Eric L.; Paul, Igor L.; Tolkoff, Marc J.

Affiliations

¹Orthopedic Research Laboratories, Harvard Medical School, Massachusetts General Hospital, Boston, Mass.

Abstract

The relationship between early degeneration of articular cartilage and the energyabsorbing abilities of its subchondral bony bed was studied in specimens obtained at autopsy from the knees of 43 male patients. Subchondral bone plugs from patients whose cartilage had only mild mucopolysaccharide loss absorbed relatively less energy on impact than the normals. There was no apparent difference in energy absorption among the bone plugs of the normal, the moderate, and the markedly altered cartilage groups. These changes were not age related.

Links

DOI: 10.1002/art.1780130406

PubMed: 4246869

WoS: A1970H021500006

History

Received: 1969-12-15

Accepted: 1970-03-03

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Cited By (31)

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1978	Radin EL, Ehrlich MG, Chernack R, Abernethy P, Paul IL, Rose RM. Effect of repetitive impulsive loading on the knee joints of rabbits. Clin Orthop Relat Res. March–April 1978;131:288-293.
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1974	Pugh JW, Radin EL, Rose RM. Quantitative studies of human subchondral cancellous bone: its relationship to the state of tts overlying cartilage. J Bone Joint Surg. March 1974;56A(2):313-321.
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1972	Pugh JW. Structure and Dynamic Properties of Trabecular Bone [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; 1972.
2010	Johnston JD. Development of a Non-Invasive Imaging Technique for Characterizing Subchondral Bone Density and Stiffness [PhD thesis]. Vancouver, BC: University of British Columbia; December 2010.
2021	Huang L. Bone, Cartilage and Their Interface: Osteochondral Changes During Very Early Osteoarthritis [PhD thesis]. University of Eastern Finland; 2021.
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2019	Knowles NK. Improving Material Mapping in Glenohumeral Finite Element Models: A Multi-Level Evaluation [PhD thesis]. University of Western Ontario; 2019.