Subchondral bone changes in patients with early degenerative joint disease

Radin, Eric L.<sup>1</sup>; Paul, Igor L.<sup>1</sup>; Tolkoff, Marc J.<sup>1</sup>

Affiliations

¹Orthopedic Research Laboratories, Harvard Medical School, Massachusetts General Hospital, Boston, Mass.

Abstract

The relationship between early degeneration of articular cartilage and the energyabsorbing abilities of its subchondral bony bed was studied in specimens obtained at autopsy from the knees of 43 male patients. Subchondral bone plugs from patients whose cartilage had only mild mucopolysaccharide loss absorbed relatively less energy on impact than the normals. There was no apparent difference in energy absorption among the bone plugs of the normal, the moderate, and the markedly altered cartilage groups. These changes were not age related.

Links

DOI: 10.1002/art.1780130406

PubMed: 4246869

WoS: A1970H021500006

History

Received: 1969-12-15

Accepted: 1970-03-03

Cited Works (4)

Year	Entry
1966	Weaver JK, Chalmers J. Cancellous bone: its strength and changes with aging and an evaluation of some methods for measuring its mineral content, I: age changes in cancellous bone. J Bone Joint Surg. March 1966;48A(2):289-298.
1968	Maroudas A, Bullough P, Swanson SAV, Freeman MAR. The permeability of articular cartilage. J Bone Joint Surg. February 1968;50B(1):166-177.
1967	Paul JP. Forces transmitted by joints in the human body. Proc Inst Mech Eng. 1967;181(pt 3J):8-15.
1970	Radin EL, Paul IL, Lowy M. A comparison of the dynamic force transmitting properties of subchondral bone and articular cartilage. J Bone Joint Surg. April 1970;52A(3):444-456.

Cited By (30)

Year	Entry
1986	Frost HM. Intermediary Organization of the Skeleton. Vols. 1-2. Boca Raton, FL: CRC Press; 1986.
1989	Benaissa R, Uhthoff HK, Mercier P. Repair of trabecular fatigue fractures: cadaver studies of the upper femur. Acta Orthop Scand. October 1989;60(5):585-589.
2000	Ding M. Age variations in the properties of human tibial trabecular bone and cartilage. Acta Orthop Scand. 2000;71(suppl 292):1-45.
1971	Radin EL, Paul IL. Response of joints to impact loading, I: in vitro wear. Arthritis Rheum. May–June 1971;14(3):356-362.
2003	Bobinac D, Spanjol J, Zoricic S, Maric I. Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans. Bone. March 2003;32(3):284-290.
1991	Grynpas MD, Alpert B, Katz I, Lieberman I, Pritzker KPH. Subchondral bone in osteoarthritis. Calcif Tiss Int. January 1991;49(1):20-26.
2002	Brown SJ, Pollintine P, Powell DE, Davie MW, Sharp CA. Regional differences in mechanical and material properties of femoral head cancellous bone in health and osteoarthritis. Calcif Tiss Int. September 2002;71(3):227-234.
1986	Radin EL, Rose RM. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res. December 1986;213:34-40.
1987	Fazzalari NL, Vernon-Roberts B, Darracott J. Osteoarthritis of the hip: possible protective and causative roles of trabecular microfractures in the head of the femur. Clin Orthop Relat Res. March 1987;216:224-233.
1985	Hvid I, Jensen NC, Bünger C, Sølund K, Djurhuus JC. Bone mineral assay: its relation to the mechanical strength of cancellous bone. Eng Med. 1985;14(2):79-83.
1988	Linde F, Gøthgen CB, Hvid I, Pongsoipetch B, Bentzen S. Mechanical properties of trabecular bone by a non‐destructive compression testing approach. Eng Med. 1988;17(1):23-29.
1972	Simon SR, Radin EL, Paul IL, Rose RM. The response of joints to impact loading, II: in vivo behavior of subchondral bone. J Biomech. May 1972;5(3):267-272.
1973	Radin EL, Parker HG, Pugh JW, Steinberg RS, Paul IL, Rose RM. Response of joints to impact loading, III: relationship between trabecular microfractures and cartilage degeneration. J Biomech. January 1973;6(1):51-57.
1973	Pugh JW, Rose RM, Radin EL. Elastic and viscoelastic properties of trabecular bone: dependence on structure. J Biomech. 1973;6(5):475-485.
1975	Townsend PR, Raux P, Rose RM, Miegel RE, Radin EL. The distribution and anisotropy of the stiffness of cancellous bone in the human patella. J Biomech. 1975;8(6):363-367.
2011	Dall'Ara E, Öhman C, Baleani M, Viceconti M. Reduced tissue hardness of trabecular bone is associated with severe osteoarthritis. J Biomech. May 17, 2011;44(8):1593-1598.
1974	Pugh JW, Radin EL, Rose RM. Quantitative studies of human subchondral cancellous bone: its relationship to the state of tts overlying cartilage. J Bone Joint Surg. March 1974;56A(2):313-321.
2003	Issever AS, Burghardt A, Patel V, Laib A, Lu Y, Ries M, Majumdar S. A micro-computed tomography study of the trabecular bone structure in the femoral head. J Musculoskel Neuron Interact. 2003;3(2):176-184.
1984	Brown TD, Vrahas MS. The apparent elastic modulus of the juxtarticular subchondral bone of the femoral head. J Orthop Res. 1984;2(1):32-38.
1984	Radin EL, Martin RB, Burr DB, Caterson B, Boyd RD, Goodwin C. Effects of mechanical loading on the tissues of the rabbit knee. J Orthop Res. 1984;2(3):221-234.
1989	Linde F, Hvid I, Pongsoipetch B. Energy absorptive properties of human trabecular bone specimens during axial compression. J Orthop Res. May 1989;7(3):432-439.
2007	Furman BD, Strand J, Hembree WC, Ward BD, Guilak F, Olson SA. Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis. J Orthop Res. May 2007;25(5):578-592.
2012	Burr DB, Gallant MA. Bone remodelling in osteoarthritis. Nat Rev Rheumatol. November 2012;8(11):665-673.
1989	Athanasiou KA. Biomechanical Assessment of Articular Cartilage Healing and Interspecies Variability [PhD thesis]. Columbia University; 1989.
2019	Ilas DC. The Role of Mesenchymal Stem Cells and Osteocytes in Subchondral Bone Changes in Hip Osteoarthritis [PhD thesis]. University of Leeds; May 2019.
1972	Pugh JW. Structure and Dynamic Properties of Trabecular Bone [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; 1972.
2010	Johnston JD. Development of a Non-Invasive Imaging Technique for Characterizing Subchondral Bone Density and Stiffness [PhD thesis]. Vancouver, BC: University of British Columbia; December 2010.
2021	Huang L. Bone, Cartilage and Their Interface: Osteochondral Changes During Very Early Osteoarthritis [PhD thesis]. University of Eastern Finland; 2021.
1991	Choi K. The Micro Mechanical Properties of Bone Tissue [PhD thesis]. University of Michigan; 1991.
2019	Knowles NK. Improving Material Mapping in Glenohumeral Finite Element Models: A Multi-Level Evaluation [PhD thesis]. University of Western Ontario; 2019.