Segmentation techniques for analysis of bone by three-dimensional computed tomographic imaging

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Dufresne, Thomas¹

Segmentation techniques for analysis of bone by three-dimensional computed tomographic imaging

Technol Health Care. 1998;6(5-6):351-359

©1998 IOS Press. All rights reserved

Affiliations

¹Procter & Gamble Pharmaceuticals; Health Care Research Center; 8340 Mason-Montgomery Road; Mason; OH 45202; USA
Abstract and keywords

Improved methods for evaluation and quantification of the three-dimensional (3D) architecture of bone are needed in order to more fully understand the role of trabecular architecture in bone strength. Computed tomography (µCT) is capable of examining bone at resolutions below 30 µm (isotropic); with collection of a three-dimensional data set which can then be subjected to image analysis. In this paper; we discuss automated methods for important steps in this analysis; including methods for (1) segmenting the image into bone and background; (2) defining the volume of interest for determination of structural parameters; and (3) segmenting the bone into trabecular and cortical components. Evaluation of bone structure using these techniques provides new information about the 3D architecture of bone tissue; and may be useful for evaluation of structural changes in bone caused by aging; disease; or drug treatment.

Keywords: Bone imaging; computed tomography; magnetic resonance imaging; segmentation techniques
Links

URL: https://content.iospress.com/articles/technology-and-health-care/thc140

PubMed: 10100938

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2004	Mulder L, Koolstra JH, Van Eijden TMGJ. Accuracy of microCT in the quantitative determination of the degree and distribution of mineralization in developing bone. Acta Radiol. November 2004;45(7):769-777.
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2019	Zenzes M, Bortel EL, Fratzl P, Mundlos S, Schuetz M, Schmidt H, Duda GN, Witte F, Zaslansky P. Normal trabecular vertebral bone is formed via rapid transformation of mineralized spicules: a high-resolution 3D ex-vivo murine study. Acta Biomater. March 1, 2019;86:429-440.
2001	Borah B, Gross GJ, Dufresne TE, Smith TS, Cockman MD, Chmielewski PA, Lundy MW, Hartke JR, Sod EW. Three‐dimensional microimaging (MRμI and μCT), finite element modeling, and rapid prototyping provide unique insights into bone architecture in osteoporosis. Anat Rec. April 15, 2001;265(2):101-110.
2004	Borah B, Dufresne TE, Chmielewski PA, Johnson TD, Chines A, Manhart MD. Risedronate preserves bone architecture in postmenopausal women with osteoporosis as measured by three-dimensional microcomputed tomography. Bone. April 2004;34(4):736-746.
2007	Buie HR, Campbell GM, Klinck RJ, MacNeil JA, Boyd SK. Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis. Bone. October 2007;41(4):505-515.
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2007	Yuan Y. The Differential Effects of Two Critical Osteoclastogenesis Stimulating Factors on Bone Biomechanics [PhD thesis]. Clemson, SC: Clemson University; May 2007.
2006	Yang S. Animal Experiment (rabbit) to Demonstrate Changes in Trabecular Bone Mechanical Properties Over Time Using Finite Element Analysis [PhD thesis]. Louisville, KY: University of Louisville; December 2006.
2008	Xu Q. Evaluation of Bone Quality Using Novel Image Analyses and Mechanical Testing Methods [PhD thesis]. Louisville, KY: University of Louisville; August 2008.
2019	Mustafy T. The Short and Long Term Effects of in Vivo Cyclic Axial Compression Applied During Puberty on Bone Growth, Morphometry and Biomechanics [PhD thesis]. École polytechnique de Montréal; July 2019.
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