Nearside occupants are at a higher risk for serious injury than far-side occupants in side impact collisions. Accidents where the driver is the only occupant accounts for more than 80% of all side impact injuries. This paper presents the results of study on sensitivity of serious injury outcome for drivers involved in nearside car to car (C2C) collisions, especially at intersection. In total, 865 intersection C2C crashes (NASS-CDS CY 2004- 2014) are analyzed in detail to determine the injury level outcome based on different crash factors, such as delta- v, age, gender, striking vehicle type, impact location (F,Y,P,Z,B-regions) and impact angle. Injury sensitivity with respect to impact location was studied in detail. A univariate logistic regression was done to check the probability of a serious injury occurring between the center and end locations. A higher number of serious to fatal injuries (57%) occurred in the Y-region when compared to other impact locations. Additionally, a higher number of serious to fatal injuries (60%) occurred when the direction of impact is 10 o‘clock. Injury occurrence for L-type offset impacts at both ends of the vehicle’s-B and F regions, were quite low. In P and Y regions (T-type impact), the chances of having AIS3+ injuries were higher for an impact angle of 10 o‘clock than those of 8 and 9 o‘clock. The probability of having AIS3+ injuries was higher in senior (age>60) drivers than in younger drivers. When the striking vehicle changed from PV to SUV, a higher number of serious injuries were observed. AIS3+ injuries in head and lower extremity (including pelvis) injuries were increased, when the striking vehicle was a SUV as compared to a PV. But, there is not much change in the thorax region. Finally, the above real world accident results were also verified with barrier to car FE simulations. A certain amount of offset of the maximum intrusion point of the deformation profile from the occupant sitting position in both the forward direction (towards A-pillar) and backward direction (towards C-pillar) influences the outcome of the driver’s injury level. Results of the present study provides opportunity for considering new interaction terms between impact locations, impact directions, occupant height, vehicle type and others in improving the accuracy of AACN ISP algorithm injury prediction in nearside lateral collision.