The objective of the current study was to evaluate the impact response of the Global Human Body Model Consortium (GHBMC) Human Body Model (HBM) by comparing its various response parameters to those obtained from Post‐Mortem Human Subjects (PMHS) experiments. In addition, rib fractures predicted by the HBM were also compared with those sustained by the PMHS. The evaluation was performed under two different impact scenarios ‐ lateral (90 degree), and oblique (60 degree). Also simulations were performed with and without pre‐tensioning in the seatbelt for each scenario. Experimental contact forces, regional accelerations and displacements were compared to those obtained from simulations for both the scenarios. The correlation between the experimental and simulation data were quantified using correlation analysis (CORA). The rib fractures and corresponding Abbreviated Injury Scale (AIS) score observed in the experiments were compared to that of simulations. The simulations with the pre‐tensioned HBM under‐predicted the number of fractures that are observed in the PMHS and the HBM predicted fractures were higher in the cases with no pre‐ tensioning compared to those of with pre‐tensioning. In the pre‐tensioned case, the HBM under‐predicted the head and T1 displacements, whereas, over predicted T12 and sacrum in both the impact cases. The average combined CORA ratings of the accelerations and contact forces for the with and without pre‐tensioning cases were 0.7 and 0.56 in the lateral impact, and the ratings were only 0.5 and 0.46 in the oblique impact. In summary, the study recommends further improvement in the biofidelity of the model under oblique loading mode by improving component level biofidelity of the GHBMC model – thoracic and lumbar spine for example.