Multiple impact crashes (MICs) consist of more than 50 percent of all tow-away crashes that occurred on US roadways between 2000 and 2008. The total number of injured occupants with MAIS3+ injury, based on NASS-CDS data for 3-point lap and shoulder belted occupants, without rollover and no-ejection for the model year 2000-08, is 1,571(weighted 109,276). No significant change or variation can be observed with respect to the model year of the vehicle. The probability of higher level of injury (MAIS>3-5) suffered by the occupants inside the vehicle, is more likely to occur in MIC scenario than that in SIC (single impact crash) scenario. As passive safety measures, especially irreversible systems, are generally more effectively designed for occupant protection in single impact, there are opportunities for future advanced active systems as mentioned by Sander (2009).