Occupant restraint system development continues to evolve as new regulations and consumer demand drive more complex solutions. Traditional seat belt and airbag designs are giving way to more intelligent systems that respond to crash and occupant conditions. In regulated vehicle compliance safety tests, occupant performance is usually judged against injury criteria that differ with respect to occupant size. While for a given test, two different occupant sizes may give results that pass the criteria, their probabilities of injury for a given body region may not be equal. It may be possible to change restraint configurations that not only demonstrate compliance to recognized injury criteria for a given occupant, but additionally demonstrate that for a given crash mode, an equal probability of injury exists for all body regions of a range of adult occupant sizes. This paper will discuss a computer modeling approach devised to analyze a particular vehicle environment and range of occupant sizes. A design of experiments was carried out that adjusted parameters of the restraint system including seat belt pretensioners, load limits, and various airbag components. For each analysis, the probability of injury by body region and occupant were compared to find the set of components that comprise a system to give equal probability of injury for each body region for each occupant. Results of the design of experiments, statistical analysis and impact on restraint system development will be discussed. This paper documents a new approach to restraint system development as it looks beyond specific injury criteria to injury risk comparisons.