This paper presents whiplash simulations and analyses under various impact conditions and acceleration levels by employing a rigorously validated biofidelic multi-body (MB) model of the whole human spine. The novel MB model possesses highly advanced material properties such as viscoelastic behaviour, active-passive muscles, and geometric nonlinearities. Validation is carried out comparing the motion segment responses, the MB model responses for frontal and lateral impacts, the vertical loading results, and the responses of thoracolumbar region in rear-end impact. The model successfully reproduces the characteristic motion of the head and neck when subjected to rear-end crash scenarios. Whiplash simulations involve not only the responses of the ligamentous spine model, but also predictions of the model with active/passive musculature. The MB model simulation results and model predictions such as head translations and rotations, muscle and ligament forces, and intervertebral angles show good agreement with experiments. The study is limited to presenting the kinematics and kinetics of the cervical spine. The biofidelic whole human spine model proves to be a highly capable and versatile platform to simulate various traumatic whiplash injury situations.