Development and Validation Af a Human Hip Joint Finite Element Model for Tissue Stress and Strain Predictions During Gait

Articular cartilage degeneration, called osteoarthritis, in the hip joint is a serious condition that affects millions of individuals yearly, with limited clinical solutions available to prevent or slow progression of damage. Additionally, the effects of high-risk factors (e.g. obesity, soft and hard tissue injuries, abnormal joint alignment, amputations) on the progression of osteoarthritis are not fully understood. Therefore, the objective of this thesis is to generate a finite element model for predicting osteochondral tissue stress and strain in the human hip joint during gait, with a future goal of using this model in clinically relevant studies aimed at prevention, treatment, and rehabilitation of OC injuries.

A subject specific finite element model (FEM) was developed from computerized tomography images, using rigid bones and linear elastic isotropic material properties for cartilage as a first step in model development. Peak contact pressures of 8.0 to 10.6 MPa and contact areas of 576 to 1010 mm2 were predicted by this FEM during the stance phase of gait. This model was validated with in vitro measurements and found to be in good agreement with experimentally measured contact pressures, and fair agreement with measured contact areas.

Keywords:

Year	Entry
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Year

Entry

2007

Ateshian GA, Ellis BJ, Weiss JA. Equivalence between short-time biphasic and incompressible elastic material responses. J Biomech Eng. June 2007;129(3):405-412.

1977

Maroudas A, Venn M. Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage, II: swelling. Ann Rheum Dis. 1977;36(5):399-406.

1987

Mak AF, Lai WM, Mow VC. Biphasic indentation of articular cartilage, I: theoretical analysis. J Biomech. 1987;20(7):703-714.

2000

Ferguson SJ, Bryant JT, Ganz R, Ito K. The influence of the acetabular labrum on hip joint cartilage consolidation: a poroelastic finite element model. J Biomech. August 2000;33(8):953-960.

1998

Ateshian GA, Wang H, Lai WM. The role of interstitial fluid pressurization and surface porosities on the boundary friction of articular cartilage. J Tribol. April 1998;120(2):241-248.