RGD modified polymers: biomaterials for stimulated cell adhesion and beyond

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Hersel, Ulrich¹; Dahmen, Claudia¹; Kessler, Horst¹

RGD modified polymers: biomaterials for stimulated cell adhesion and beyond

Biomaterials. November 2003;24(24):4385-4415

©2003 Elsevier Ltd. All rights reserved.

Affiliations

¹Institut fur Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstr. 4, D-85747, Garching, Germany
Abstract and keywords

Since RGD peptides (R: arginine; G: glycine; D: aspartic acid) have been found to promote cell adhesion in 1984 (Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule, Nature 309 (1984) 30), numerous materials have been RGD functionalized for academic studies or medical applications. This review gives an overview of RGD modified polymers, that have been used for cell adhesion, and provides information about technical aspects of RGD immobilization on polymers. The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed.

Keywords: RGD peptide; Integrin; Polymer modification; Cell attachment; Cell behavior; Review
Links

DOI: 10.1016/S0142-9612(03)00343-0

PubMed: 12922151

WoS: 000185037700006

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