Variations in Knee Articular Cartilage Morphology Are Associated With Biomechanics of Gait for Healthy, Osteoarthritic and ACL Deficient Subjects

Trauma, joint injuries and biological changes in the tissue can initiate the degeneration of cartilage and progress to osteoarthritis (OA). Accurate measurements of articular cartilage morphology helps understand cartilage physiology and monitor the progression of OA.

The objectives of this study were 1) to develop software to create three-dimensional (3D) cartilage models from magnetic resonance (MR) images and measure cartilage thickness in the regions of interest, 2) to understand in vivo functional adaptations of knee articular cartilage to biomechanical loading during walking, and 3) to study the cartilage thinning pattern of subjects with anterior cruciate ligament (ACL) rupture in relation to the knee kinematic changes during walking.

Methods that can delineate articular cartilage boundaries in MR images and build 3D surface models were developed. The accuracy of the articular cartilage model was evaluated using resected tibial plateau samples from total knee replacement patients. The dynamic loading in the knee during walking was compared to the knee articular cartilage thicknesses to understand the in vivo functional adaptation of articular cartilage in healthy, OA and ACL deficient subjects (2). The kinematic changes during walking in the ACL deficient knees relative to contralateral healthy knees were compared with the spatial cartilage thickness differences between the bilateral knees (3).

The results showed that healthy subjects had thicker cartilage with higher joint load, while OA subjects had thinner cartilage with higher joint load during walking. In addition, body mass index and contact surface shapes which can affect the local mechanical stress in cartilage were also associated with cartilage thicknesses in relatively young healthy subjects. The change in knee kinematics during walking after ACL rupture seems to influence cartilage thinning pattern in the early stage for ACL deficient subjects.

The development and validation of this software enables the investigation of the biomechanical factors that initiate and progress OA. In the future, the effects of biomechanical factors on cartilage physiology will be further investigated using the tool to understand the pathways of OA and prevent and treat OA.

Year	Entry
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2005	Andriacchi TP, Dyrby CO. Interactions between kinematics and loading during walking for the normal and ACL deficient knee. J Biomech. February 2005;38(2):293-298.
1998	Andriacchi TP, Alexander EJ, Toney MK, Dyrby C, Sum J. A point cluster method for in vivo motion analysis: applied to a study of knee kinematics. J Biomech Eng. December 1998;120(6):743-749.
1991	Schipplein OD, Andriacchi TP. Interaction between active and passive knee stabilizers during level walking. J Orthop Res. January 1991;9(1):113-119.
1998	Sharma L, Hurwitz DE, Thonar EJ-MA, Sum JA, Lenz ME, Dunlop DD, Schnitzer TJ, Kirwan-Mellis G, Andriacchi TP. Knee adduction moment, serum hyaluronan level, and disease severity in medial tibiofemoral osteoarthritis. Arthritis Rheum. July 1998;41(7):1233-1240.
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Year

Entry

2000

Smith RL, Lin J, Trindade MCD, Shida J, Kajiyama G, Vu T, Hoffman AR, van der Meulen MCH, Goodman SB, Schurman DJ, Carter DR. Time-dependent effects of intermittent hydrostatic pressure on articular chondrocyte type II collagen and aggrecan mRNA expression. J Rehab Res Dev. March–April 2000;37(2):153-181.

2005

Andriacchi TP, Dyrby CO. Interactions between kinematics and loading during walking for the normal and ACL deficient knee. J Biomech. February 2005;38(2):293-298.

1998

Andriacchi TP, Alexander EJ, Toney MK, Dyrby C, Sum J. A point cluster method for in vivo motion analysis: applied to a study of knee kinematics. J Biomech Eng. December 1998;120(6):743-749.

1991

Schipplein OD, Andriacchi TP. Interaction between active and passive knee stabilizers during level walking. J Orthop Res. January 1991;9(1):113-119.

1998

Sharma L, Hurwitz DE, Thonar EJ-MA, Sum JA, Lenz ME, Dunlop DD, Schnitzer TJ, Kirwan-Mellis G, Andriacchi TP. Knee adduction moment, serum hyaluronan level, and disease severity in medial tibiofemoral osteoarthritis. Arthritis Rheum. July 1998;41(7):1233-1240.