Structural specialization in tendons under compression

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Vogel, Kathryn G.¹; Koob, Thomas J.¹

Structural specialization in tendons under compression

Int Rev Cytol. 1989;115:267-293

©1989 Academic Press Inc.

Affiliations

¹Department of Biology, The University of New Mexico, Albuquerque, New Mexico 87131
Abstract

This chapter describes the dynamic characteristic of tendon––the ability of a tendon to modulate its structural and material properties to meet mechanical requirements distinct from the usual need for strength in tension. Tendon performs the mechanical role of transmitting the tensional force generated by contraction of its muscle of origin to the bone upon which it inserts. The histology, biochemistry, and cell biology of regions of the flexor digitorum profundus tendon (deep digital flexor tendon) either subjected to tension or to compression are described in the chapter. The hypothesis that tendon fibroblasts and the extracellular matrix they produce are modulated according to their mechanical requirements is explored. The development of cartilaginous tissue in the region of tendon subjected to compressive forces is genetically programmed. The stimulus to produce large Proteoglycan (PG) is generated by one or more soluble factors that are released under defined conditions and carried systemically to a population of target cells. Many fibroblasts in adult tissue have the capacity to generate a cartilage like tissue.
Links

DOI: 10.1016/S0074-7696(08)60632-4

PubMed: 2663761

WoS: A1989AJ65900006

Cited Works (4)

Year	Entry
1984	Hubbard RP, Soutas-Little RW. Mechanical properties of human tendon and their age dependence. J Biomech Eng. May 1984;106(2):144-150.
1987	Frank EH, Grodzinsky AJ, Koob TJ, Eyre DR. Streaming potentials: a sensitive index of enzymatic degradation in articular cartilage. J Orthop Res. 1987;5(4):497-508.
1977	von der Mark K, Gauss V, von der Mark H, Müller P. Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature. June 9, 1977;267(5611):531-532.
1959	Rigby BJ, Hirai N, Spikes JD, Eyring H. The mechanical properties of rat tail tendon. J Gen Physiol. November 1959;43(2):265-283.

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2004	AufderHeide AC, Athanasiou KA. Mechanical stimulation toward tissue engineering of the knee meniscus. Ann Biomed Eng. August 2004;32(8):1161-1174.
2021	Ma C, Jing Y, Li H, Wang K, Wang Z, Xu C, Sun X, Kaji D, Han X, Huang A, Feng JQ. Scx^Lin cells directly form a subset of chondrocytes in temporomandibular joint that are sharply increased in Dmp1-null mice. Bone. January 2021;142:115687.
1998	Benjamin M, Ralphs JR. Fibrocartilage in tendons and ligaments: an adaptation to compressive load. J Anat. 1998;193(4):481-494.
2006	Benjamin M, Toumi H, Ralphs JR, Bydder G, Best TM, Milz S. Where tendons and ligaments meet bone: attachment sites (‘entheses’) in relation to exercise and/or mechanical load. J Anat. April 2006;208(4):471-490.
2006	Wang JH-C. Mechanobiology of tendon. J Biomech. 2006;39(9):1563-1582.
2023	Muljadi PM, Andarawis-Puri N. Glycosaminoglycans modulate microscale mechanics and viscoelasticity in fatigue injured tendons. J Biomech. May 2023;152:111584.
1993	Giori NJ, Beaupré GS, Carter DR. Cellular shape and pressure may mediate mechanical control of tissue composition in tendons. J Orthop Res. July 1993;11(4):581-591.
1996	Berenson MC, Blevins FT, Plaas AHK, Vogel KG. Proteoglycans of human rotator cuff tendons. J Orthop Res. July 1996;14(4):518-525.
2023	Ozone K, Minegishi Y, Takahata K, Takahashi H, Yoneno M, Hattori S, Xianglan L, Oka Y, Murata K, Kanemura N. Eccentric contraction-dominant exercise leads to molecular biological changes in enthesis and enthesopathy-like morphological changes. J Orthop Res. March 2023;41(3):511-523.
1998	Lotz JC, Colliou OK, Chin JR, Duncan NA, Liebenberg E. Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study. Spine. December 1, 1998;23(23):2493-2506.
2007	Jiang J. The Role of Cellular Interactions in Osteochondral Graft Design and the Maintenance of a Stable Osteochondral Interface [PhD thesis]. Columbia University; 2007.
2008	Spalazzi JP. Biomimetic Multi-Phasic Scaffold Design for Orthpaedic Interface Tissue Engineering [PhD thesis]. Columbia University; 2008.
2009	Wang I-N. Role of Heterotypic Cellular Interactions in the Regeneration of the Anterior Cruciate Ligament-to-Bone Interface [PhD thesis]. Columbia University; 2009.
2022	Muljadi PM. The Role of Glycosaminoglycans in Fatigue Injured Tendon [PhD thesis]. Ithaca, NY: Cornell University; May 2022.
2011	Rigozzi S. Structure and Function in Tendon: Experimental Studies on the Ultrastructural Determinants of Tendon Biomechanical Function [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2011.
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2016	Shiovitz DA. Scarless Tendon Healing in MRL/MpJ Mice Suggests Tissue-Driven Mechanisms of Regeneration [PhD thesis]. Icahn School of Medicine at Mount Sinai; 2016.
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2006	Aufderheide AC. Mechanical Stimulation Towards Tissue Engineering of the Knee Meniscus [PhD thesis]. Houston, TX: Rice University; June 2006.
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1999	Kukreti U. Structure-Function Relationship in Connective Tissues: A Study of Rabbit Medial Collateral Ligaments [PhD thesis]. Baltimore County, University of Maryland; 1999.
1998	Derwin KA. A Quantitative Investigation of Structure-Function Relationships in a Tendon Fascicle Model [PhD thesis]. University of Michigan; 1998.
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2010	Peltz CD. The Role of Altered Loading in Pathological Changes in the Long Head of the Biceps Tendon Following Rotator Cuff Tears in a Rat Model [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
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