Measures of Individual Resorption Cavities in Three-Dimensional Images in Cancellous Bone

Resorption cavities result from the activity of osteoclasts, cells that remove old or damaged tissue during bone remodeling. These cavities are believed to act as stress risers, potentially impairing bone strength and increasing fracture risk. Estrogen depletion has been associated with an increase in bone remodeling, but it is unclear whether the change is due to an increase in the number of cavities, surface area of individual cavities, or both. The distribution of stress concentration due to cavities may be related to their number and size, independent of the amount of bone remodeling. Here we present and validate the first, 3D approach to measuring individual resorption cavities in cancellous bone. Additionally, cavity number and surface area are compared in a standard animal model of post-menopausal osteoporosis, the ovarietomized rat.

Year	Entry
1990	Mosekilde L. Consequences of the remodelling process for vertebral trabecular bone structure: a scanning electron microscopy study (uncoupling of unloaded structures). Bone Miner. July 1990;10(1):13-35.
2006	Hernandez CJ, Gupta A, Keaveny TM. A biomechanical analysis of the effects of resorption cavities on cancellous bone strength. J Bone Miner Res. August 2006;21(8):1248-1255.
1987	Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR. Bone histomorphometry: standardization of nomenclature, symbols, and units: report of the ASBMR histomorphometry nomenclature committee. J Bone Miner Res. December 1987;2(6):595-610.
1984	Eriksen EF, Melsen F, Mosekilde L. Reconstruction of the resorptive site in iliac trabecular bone: a kinetic model for bone resorption in 20 normal individuals. Metab Bone Dis Rel Res. 1984;5(5):235-242.
2006	Hernandez CJ, Keaveny TM. A biomechanical perspective on bone quality. Bone. December 2006;39(6):1173-1181.
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Year

Entry

1990

Mosekilde L. Consequences of the remodelling process for vertebral trabecular bone structure: a scanning electron microscopy study (uncoupling of unloaded structures). Bone Miner. July 1990;10(1):13-35.

2006

Hernandez CJ, Gupta A, Keaveny TM. A biomechanical analysis of the effects of resorption cavities on cancellous bone strength. J Bone Miner Res. August 2006;21(8):1248-1255.

1987

Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR. Bone histomorphometry: standardization of nomenclature, symbols, and units: report of the ASBMR histomorphometry nomenclature committee. J Bone Miner Res. December 1987;2(6):595-610.

1984

Eriksen EF, Melsen F, Mosekilde L. Reconstruction of the resorptive site in iliac trabecular bone: a kinetic model for bone resorption in 20 normal individuals. Metab Bone Dis Rel Res. 1984;5(5):235-242.

2006

Hernandez CJ, Keaveny TM. A biomechanical perspective on bone quality. Bone. December 2006;39(6):1173-1181.