Genetic factors in determining bone mass

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Smith, David M.¹; Nance, Walter E.¹; Kang, Ke Won¹; Christian, Joe C.¹; Johnston, Jr, C. Conrad¹

Genetic factors in determining bone mass

J Clin Invest. 1973;52(11):2800-2808

Affiliations

¹Indiana University School of Medicine, Indianapolis, Indiana 46202
Abstract

This investigation was undertaken to evaluate possible genetic determinants of bone mass with the premise that inheritance of bone mass could be of etiologic importance in osteoporosis.

Bone mass and width measurements were made with the photon absorption technique on the right radius of 71 juvenile and 80 adult twin paris. The variance of intrapair differences of bone mass in monozygotic (MZ) juvenile twins was 0.0013 g²/cm² compared to 0.0052 g²/cm² in the dizygotic (DZ) twins. For the adult twins the variance of intrapair differences in bone mass was 0.0069 for MZ and 0.0137 for DZ twins. Similar results were obtained for bone width. The significantly larger variation in intrapair differences in DZ twins indicates that these traits have significant genetic determinants. These intrapair differences were found to increase with age, suggesting that genetic-environmental interaction also contributes to the observed variation in bone mass.

These data provide evidence that bone mass does have significant genetic factors, which alone or in conjunction with environmental factors may predispose persons to the development of osteoporosis.
Links

DOI: 10.1172/JCI107476

PubMed: 4795916

WoS: A1973R188400017
History

Received: 1973-04-27

Revised: 2973-07-09

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Cited By (35)

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2022	Moran MM, Ko FC, Mesner LD, Calabrese GM, Al-Barghouthi BM, Farber CR, Sumner DR. Intramembranous bone regeneration in diversity outbred mice is heritable. Bone. November 2022;164:116524.
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2021	Yau MS, Kuipers AL, Price R, Nicolas A, Tajuddin SM, Handelman SK, Arbeeva L, Chesi A, Hsu Y, Liu C, Karasik D, Zemel BS, Grant SF, Jordan JM, Jackson RD, Evans MK, Harris TB, Zmuda JM, Kiel DP. A meta‐analysis of the transferability of bone mineral density genetic loci associations from European to African ancestry populations. J Bone Miner Res. March 2021;36(3):469-479.
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