Quantitative microradiographic studies of normal and osteoporotic bone

Jowsey, Jenifer<sup>1</sup>; Kelly, Patrick J.<sup>1</sup>; Riggs, B. Lawrence<sup>1</sup>; Bianco, Jr, Anthony J.<sup>1</sup>; Scholz, Donald A.<sup>1</sup>; Gershon-Cohen, J.<sup>2</sup>

Affiliations

¹Mayo Clinic and Mayo Foundation, Sections of Surgical Research (Orthopaedics), Orthopedic Surgery, and Medicine

²Albert Einstein Medical Center, Philapelphia

Abstract

Quantitative microradiography has been developed for studying bone turnover and has been applied to a study of normal and osteoporotic human bone. Evidence is presented that this method is reproducible and provides an accurate measure of bone formation and resorption. It was demonstrated that bone from the majority of osteoporotic patients differs from normal bone by an increase in the amount of resorption. Bone formation levels are generally normal; however, in Cushing's syndrome, after corticosteroid therapy, and after immobilization, bone formation decreases.

Links

DOI: 10.2106/00004623-196547040-00014

PubMed: 14302381

WoS: A19656544400013

Ovid: 00004623-196547040-00014

Cited Works (2)

Year	Entry
1959	Rowland RE, Jowsey J, Marshall JH. Microscopic metabolism of calcium in bone, III: microradiographic measurements of mineral density. Radiat Res. February 1959;10(2):234-242.
1960	Jowsey J. Age changes in human bone. Clin Orthop. 1960;17:210-218.

Cited By (25)

Year	Entry
1978	Melsen F, Melsen B, Mosekilde L, Bergmann S. Histomorphometric analysis of normal bone from the iliac crest. Acta Pathol Microbiol Scand. July 1978;86A(1-6):70-81.
1983	Parfitt AM. Stereologic basis of bone histomorphometry: theory of quantitative micorscopy and reconstruction of the third dimension. In: Recker RR, ed. Bone Histomorphometry: Techniques and Interpretation. Boca Raton, FL: Inc., CRC Press; 1983:53-87.
1983	Frost HM. Bone histomorphometry: analysis of trabecular bone dynamics. In: Recker RR, ed. Bone Histomorphometry: Techniques and Interpretation. Boca Raton, FL: Inc., CRC Press; 1983:109-131.
1983	Parfitt AM. The physiologic and clinical significance of bone histomorphometric data. In: Recker RR, ed. Bone Histomorphometry: Techniques and Interpretation. Boca Raton, FL: Inc., CRC Press; 1983:143-223.
1970	Merz WA, Schenk RK. Quantitative structural analysis of human cancellous bone. Acta Anat. 1970;75(1):54-66.
1970	Merz WA, Schenk RK. A quantitative histological study on bone formation in human cancellous bone. Acta Anat. 1970;76(1):1-15.
1993	Riggs CM, Vaughan LC, Evans GP, Lanyon LE, Boyde A. Mechanical implications of collagen fibre orientation in cortical bone of the equine radius. Anat Embryol. March 1993;187(3):239-248.
2001	Bell KL, Loveridge N, Reeve J, Thomas CDL, Feik SA, Clement JG. Super‐osteons (remodeling clusters) in the cortex of the femoral shaft: influence of age and gender. Anat Rec. December 1, 2001;264(4):378-386.
1987	Weinstein RS, Hutson MS. Decreased trabecular width and increased trabecular spacing contribute to bone loss with aging. Bone. 1987;8(3):137-142.
1997	Meunier PJ, Boivin G. Bone mineral density reflects bone mass but also the degree of mineralization of bone: therapeutic implications. Bone. November 1997;21(5):373-377.
2004	Follet H, Boivin G, Rumelhart C, Meunier PJ. The degree of mineralization is a determinant of bone strength: a study on human calcanei. Bone. May 2004;34(5):783-789.
1985	Wronski TJ, Lowry PL, Walsh CC, Ignaszewski LA. Skeletal alterations in ovariectomized rats. Calcif Tiss Int. May 1985;37(3):324-328.
2002	Boivin G, Meunier PJ. The degree of mineralization of bone tissue measured by computerized quantitative contact microradiography. Calcif Tiss Int. June 2002;70(6):503-511.
1969	Frost HM. Tetracycline-based histological analysis of bone remodeling. Calcif Tiss Res. 1969;3(1):211-237.
1987	Aaron JE, Makins NB, Sagreiya K. The microanatomy of trabecular bone loss in normal aging men and women. Clin Orthop Relat Res. February 1987;215:260-271.
1966	Jowsey J. Studies of Haversian systems in man and some animals. J Anat. October 1966;100(4):857-864.
1993	Skedros JG, Bloebaum RD, Bachus KN, Boyce TM. The meaning of graylevels in backscattered electron images of bone. J Biomed Mater Res. January 1993;7(1):47-56.
1993	Skedros JG, Bloebaum RD, Bachus KN, Boyce TM, Constantz B. Influence of mineral content and composition on graylevels in backscattered electron images of bone. J Biomed Mater Res. January 1993;27(1):57-64.
1987	Reid SA, Boyde A. Changes in the mineral density distribution in human bone with age: image analysis using backscattered electrons in the SEM. J Bone Miner Res. February 1987;2(1):13-22.
1990	Eriksen EF, Hodgson SF, Eastell R, Cedel SL, O'Fallon WM, Riggs BL. Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels. J Bone Miner Res. April 1990;5(4):311-319.
1999	Bell KL, Loveridge N, Power J, Garrahan N, Stanton M, Lunt M, Meggitt BF, Reeve J. Structure of the femoral neck in hip fracture: cortical bone loss in the inferoanterior to superoposterior axis. J Bone Miner Res. January 1999;14(1):111-119.
1983	Kragstrup J, Melsen F, Mosekilde L. Thickness of bone formed at remodeling sites in normal human iliac trabecular bone: variations with age and sex. Metab Bone Dis Rel Res. 1983–1984;5(1):17-21.
1986	Boyde A, Maconnachie E, Reid SA, Delling G, Mundy GR. Scanning electron-microscopy in bone pathology: review of methods, potential and applications. Scan Electron Microsc. 1986;1986(4):1537-1554.
1987	Stover SM. Dorsal Metacarpal Disease in Thoroughbred Horses: Relationship to the Development of the Third Metacarpal Bone [PhD thesis]. Davis, University of California; 1987.
1998	Vajda EG. Age-Related Changes in the Microstructure and Mineralization of the Female Proximal Femur [PhD thesis]. University of Utah; March 1998.