A model of lifetime osteoporosis impact

Chrischilles, Elizabeth A.; Butler, C. David; Davis, Charles S.; Wallace, Robert B.

Affiliations

¹Department of Preventive Medicine and Environmental Health, University of Iowa, Iowa City

²Burroughs Wellcome Scholar in Pharmacoepidemiology

³College of Pharmacy, University of Iowa, Iowa City

⁴Present address: University Hospital Consortium, Oak Brook, Ill

Abstract

The study goal was to use population-based data to model aspects of lifetime osteoporosis impact not previously studied, specifically: (1) to estimate person-years of fracturerelated functional impairment against the trajectory of functional status in the general population; (2) jointly to consider hip, vertebral, and Colles' fractures in estimating the percent of women who will ever fracture; and (3) to estimate the lifetime number of fractures expected in a cohort of 10 000 50-year-old white postmenopausal women. The model estimates that 54% of 50-year-old women will sustain osteoporosis-related fractures during their remaining lifetimes. Beyond the functional impairment expected in similarly aged, unfractured women, osteoporosis-related fractures are estimated to cause 6.7% of women to become dependent in basic activities of daily living; 7.8% are expected to require nursing home care for an average of 7.6 years.

Links

DOI: 10.1001/archinte.151.10.2026

PubMed: 1929691

WoS: A1991GK64100017

History

Accepted: 1991-04-22

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Cited By (26)

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