Changes in mean trabecular orientation in the medial condyle of the proximal tibia in osteoarthritis

Kamibayashi, L.<sup>1</sup>; Wyss, U. P.<sup>2</sup>; Cooke, T. D. V.<sup>3</sup>; Zee, B.<sup>4</sup>

Affiliations

¹Department of Anatomy and Cell Biology, Queen's University, Kingston, Canada

²Clinical Mechanics Group, Queen's University, Kingston, Canada

³King Faisal Specialist Hospital, Riyadh, Kingdom of Saudi Arabia

⁴Clinical Trials Group ,Queen's University, Kingston, Canada

Abstract and keywords

In osteoarthritis of the knee, degenerative changes occur in the articular cartilage and underlying subchondral bone, particularly of the medial tibial condyle. Cancellous bone sclerosis that accompanies osteoarthritis is not only the result of an increase in bone volume fraction but also a change in trabecular structure. In a comparison with agematched controls (n=4), osteoarthritis (n=11) demonstrated a significant (P≤0.05) increase in bone volume fraction and trabecular thickness. Overal trabecular orientation in the osteoarthritic group was more vertical or perpendicular to the articular surface than the control group (P≤0.05) especially in the trabeculae of the cancellous bone layer closest to the articular surface. These alterations in trabecular bone structure could have significant consequences for the mechanical properties of osteoarthritic bone.

Keywords: Trabecular orientation; Osteoarthritis; Medial tibial condyle; Subchondral sclerosis

Links

DOI: 10.1007/BF00299000

PubMed: 7671169

WoS: A1995RE82000014

History

Received: 1994-06-30

Accepted: 1994-11-28

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Cited By (12)

Year	Entry
2002	Currey JD. Bones: Structure and Mechanics. Princeton, NJ: Princeton University Press; 2002.
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2000	Ding M, Hvid I. Quantification of age-related changes in the structure model type and trabecular thickness of human tibial cancellous bone. Bone. March 2000;26(3):291-295.
2000	Day JS, Ding M, Odgaard A, Sumner DR, Hvid I, Weinans H. Parallel plate model for trabecular bone exhibits volume fraction-dependent bias. Bone. November 2000;27(5):715-720.
2002	Brown SJ, Pollintine P, Powell DE, Davie MW, Sharp CA. Regional differences in mechanical and material properties of femoral head cancellous bone in health and osteoarthritis. Calcif Tiss Int. September 2002;71(3):227-234.
2004	Nägele E, Kuhn V, Vogt H, Link TM, Müller R, Lochmüller E-M, Eckstein F. Technical considerations for microstructural analysis of human trabecular bone from specimens excised from various skeletal sites. Calcif Tiss Int. 2004;75(1):15-22.
2011	Tassani S, Particelli F, Perilli E, Traina F, Baruffaldi F, Viceconti M. Dependence of trabecular structure on bone quantity: a comparison between osteoarthritic and non-pathological bone. Clin Biomech (Bristol, Avon). July 2011;26:632-639.
2010	Tassani S, Öhman C, Baleani M, Baruffaldi F, Viceconti M. Anisotropy and inhomogeneity of the trabecular structure can describe the mechanical strength of osteoarthritic cancellous bone. J Biomech. April 19, 2010;43(6):1160-1166.
2021	Bennison MBL, Pilkey AK, Lievers WB. Misalignment error in cancellous bone apparent elastic modulus depends on bone volume fraction and degree of anisotropy. J Biomech Eng. February 2021;143(2):021005.
2020	Bennison MBL. The Role of Cancellous Bone Architecture in Misalignment and Side Effect Errors [Master's thesis]. Sudbury, ON: Laurentian University; 2020.
2001	Boyd SK. Microstructural Bone Adaptation in an Experimental Model of Osteoarthritis [PhD thesis]. Calgary, AB: University of Calgary; January 2001.