Fifty years of brain tissue mechanical testing:​ from in vitro to in vivo investigations

Chatelin, Simon<sup>1</sup>; Constantinesco, André<sup>1,2</sup>; Willinger, Rémy<sup>1</sup>

Affiliations

¹University of Strasbourg, IMFS-CNRS, Strasbourg, France

²Nuclear Medicine Department, CHRU Hautepierre, Strasbourg, France

Abstract and keywords

Beginning in the 1960s many studies have been performed to investigate the mechanical properties of brain. In this paper we point out the difficulties linked with in vitro experimental protocols as well as the advantages of using recently developed non-invasive in vivo techniques, such as magnetic resonance elastography. Results of in vitro and in vivo work are compared, emphasizing the specificities and disparities of the in vitro as well as the in vivo results. In particular, a detailed discussion of the results obtained from dynamic shear experiments and magnetic resonance elastography is given before arriving at a tentative conclusion on the state of knowledge of the mechanical properties of brain.

Keywords: Literature review, magnetic resonance elastography, rheology

Links

DOI: 10.3233/BIR-2010-0576

PubMed: 21403381

WoS: 000288321700001

History

Received: 2010-06-04

Revised: 2010-11-26

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