Biomechanical tolerances for diffuse brain injury and a hypothesis for genotypic variability in response to trauma

Gennarelli, Thomas A.; Pintar, Frank A.; Yoganandan, Narayan

Affiliations

¹Department of Neurosurgery, Medical College of Wisconsin

Links

PubMedCentral: PMC3217573

Cited Works (6)

Year	Entry
2001	Hardy WN, Foster CD, Mason MJ, Yang KH, King AI, Tashman S. Investigation of head injury mechanisms using neutral density technology and high-speed biplanar x-ray. Stapp Car Crash J. 2001;45:337-368. SAE 2001-22-0016.
1974	Ommaya AK, Gennarelli TA. Cerebral concussion and traumatic unconsciousness: correlation of experimental and clinical observations of blunt head injuries. Brain. December 1974;97(4):633-654.
1998	The Abbreviated Injury Scale-1990 Revision, Update 1998. Des Plaines, IL: Association for the Advancement of Automotive Medicine (AAAM); 1998.
2000	Newman JA, Shewchenko N, Welbourne E. A proposed new biomechanical head injury assessment function: the maximum power index. Stapp Car Crash J. 2000;44:215-247. SAE 2000-01-SC16.
1992	Margulies SS, Thibault LE. A proposed tolerance criterion for diffuse axonal injury in man. J Biomech. August 1992;25(8):917-923.
2002	Ommaya AK, Goldsmith W, Thibault L. Biomechanics and neuropathology of adult and paediatric head injury. Br J Neurosurg. June 2002;16(3):220-242.

Cited By (24)

Year	Entry
2014	Penzkofer R, Barnsteiner K, Dendorfer S. The influence of age, shoe type and kicking direction on the severity of head trauma. J Forensic Biomech. 2014;5(1):1000102.
2009	Feist F, Gugler J, Arregui-Dalmases C, del Pozo de Dios E, López-Valdés F, Deck C, Willinger R. Pedestrian collisions with flat-fronted vehicles: injury patterns and importance of rotational accelerations as a predictor for traumatic brain injury (TBI). In: Proceedings of the 21st International Technical Conference on the Enhanced Safety of Vehicles (ESV). June 15-18, 2009; Stuttgart, Germany.
2006	Fijalkowski RJ, Stemper BD, Ellingson BM, Yoganandan N, Pintar FA, Gennarelli TA. Inducing mild traumatic brain injury in the rodent through coronal plane angular acceleration. In: Proceedings of the 2006 International IRCOBI Conference on the Biomechanics of Impact. September 20-22, 2006; Madrid, Spain.115-125.
2006	Yoganandan N, Pintar FA, Maiman D, Phillippens M, Wismans J. Head linear and rotational accelerations and craniocervical loads in lateral impact. In: Proceedings of the 2006 International IRCOBI Conference on the Biomechanics of Impact. September 20-22, 2006; Madrid, Spain.127-141.
2007	Fijalkowski RJ, Stemper BD, Pintar FA, Yoganandan N, Gennarelli TA. Influence of angular acceleration duration on functional outcomes following mild diffuse brain injury. In: Proceedings of the 2007 International IRCOBI Conference on the Biomechanics of Impact. September 19-21, 2007; Maastricht, The Netherlands.161-171.
2008	Yoganandan N, Pintar FA, Maiman DJ, Philippens M, Wismans J. Head kinematics, neck loads, and injuries in side impact sled tests. In: Proceedings of the 2008 International IRCOBI Conference on the Biomechanics of Impact. September 17-19, 2008; Bern, Switzerland.179-193.
2008	Zhang L, Yang K, Gennarelli TA. Mathematical modeling of cerebral concussion: correlations of brain strain with clinical symptoms. In: Proceedings of the 2008 International IRCOBI Conference on the Biomechanics of Impact. September 17-19, 2008; Bern, Switzerland.123-132.
2009	Crandall J. Simulating the road forward: the role of computational modeling in realizing future opportunities in traffic safety. In: Proceedings of the 2009 International IRCOBI Conference on the Biomechanics of Impact. September 9-11, 2009; York, UK.3-27.
2011	Zhang L, Gennarelli TA. Mathematical modeling of diffuse brain injury: correlations of foci and severity of brain strain with clinical symptoms and pathology. In: Proceedings of the 2011 International IRCOBI Conference on the Biomechanics of Injury. September 14-16, 2011; Krakow, Poland.315-324.
2015	Gennarelli TA. The centripetal theory of concussion (CTC) revisited after 40 years and a proposed new symptomcentric concept of the concussions. In: Proceedings of the 2015 International IRCOBI Conference on the Biomechanics of Injury. September 9-11, 2015; Lyon, France.viii-xiii.
2015	Stemper BD, Shah AS, Budde MD, Chiariello R, Wilkins N, Olsen C, Mehta P, Kurpad SN, McCrea M, Pintar FA. Characterization of differing time‐course of cognitive deficits and emotional changes following rotational traumatic brain injury in the rat. In: Proceedings of the 2015 International IRCOBI Conference on the Biomechanics of Injury. September 9-11, 2015; Lyon, France.198-207.
2019	Gennarelli TA. Back to the basics: revisiting the future, a retrospective of reminiscences. In: Proceedings of the 2019 International IRCOBI Conference on the Biomechanics of Injury. September 11-13, 2019; Florence, Italy.i-viii.
2020	Stemper BD, Shah AS, Chiariello R, McCarthy C, Budde MD, Olsen C, McCrea M. Behavioural changes associated with repeated subconcussive head impact exposures in rats: preliminary evidence of a second mechanism for concussion. In: Proceedings of the 2020 International IRCOBI Conference on the Biomechanics of Injury. 2020; Munich, Germany.594-595.
2011	Li Y, Zhang L, Kallakuri S, Zhou R, Cavanaugh JM. Injury predictors for traumatic axonal injury in a rodent head impact acceleration model. Stapp Car Crash J. 2011;55:25-47.
2007	Fijalkowski RJ, Stemper BD, Pintar FA, Yoganandan N, Crowe MJ, Gennarelli TA. New rat model for diffuse brain injury using coronal plane angular acceleration. J Neurotrauma. August 2007;24(8):1387-1398.
2004	Stemper BD, Yoganandan N, Pintar FA. Gender- and region-dependent local facet joint kinematics in rear impact: implications in whiplash injury. Spine. October 15, 2004;29(16):1764-1771.
2016	Antona-Makoshi J. Traumatic Brain Injuries: Animal Experiments and Numerical Simulations to Support the Development of a Brain Injury Criterion [PhD thesis]. Götenburg, Sweden: Chalmers University of Technology; 2016.
2023	Baker C. AutoTriage: A Feasibility Assessment of Using in-Vehicle Sensors to Predict Traumatic Brain Injury in Road Traffic Collisions [PhD thesis]. Imperial College London; March 23, 2023.
2004	Stemper BD. Whiplash Affects Cervical Spine Biomechanics [PhD thesis]. Marquette University; May 2004.
2008	Fijalkowski RJ. Rotational Acceleration Pulse Characteristics Affect Mild Diffuse Brain Injury Severity [PhD thesis]. Marquette University; May 2008.
2023	Juste Lorente Ó. Guidelines for Improving Motorcycle Helmet Testing Standards [PhD thesis]. Universidad de Zaragoza; February 2023.
2015	Singh D. Investigation of Primary Blast Injury and Protection Using Sagittal and Transverse Finite Element Head Models [Master's thesis]. University of Waterloo; 2015.
2015	Li Y. An Investigation of the Relationship Between Axonal Injury, Biomarker Expression and Mechanical Response in a Rodent Head Impact Acceleration Model [PhD thesis]. Detroit, MI: Wayne State University; 2015.
2018	Arora T. Development of a Subhuman Primate Brain Finite Element Model to Investigate Brain Injury Thresholds Induced by Head Rotation [Master's thesis]. Detroit, MI: Wayne State University; August 2018.