Abdominal injuries are a relatively common result of motor vehicle crashes and the injuries represent a high proportion of serious injuries. Previous work has shown a correlation between vascular pressure and liver injury in human surrogates and in pressurized ex vivo human and porcine livers when subjected to blunt impact. The purpose of this work was to further investigate the relationship between pressure and liver injury using post-mortem human subjects (PMHS). Specifically, the goals were to (1) conduct lateral impacts on PMHS with repressurized abdominal vascular systems and measure the vascular pressure and (2) determine if a correlation exists between the measured vascular pressure and liver injury. In an ongoing study, four PMHS have been instrumented with pressure sensors in the abdominal vessels, including the abdominal aorta, the hepatic veins, and the inferior vena cava. For each test, the subject’s abdomen was pressurized to physiological pressures using saline. The seated subject was held upright by a head restraint which was released immediately before contact by the pneumatic ram, ensuring the subject was not suspended at the time of impact. The lateral impact was applied to the right side of the subject at the level of the liver. Following each test, autopsy was performed on the subject. One test resulted in a serious (AIS 3+) injury to the liver. The test in which a liver injury was obtained resulted in the highest peak hepatic vein pressure and the highest peak rate of pressure increase. The compression (C), viscous criteria ([V(t)*C(t)]max), and abdominal injury criteria (VmaxCmax) were also highest for this test. These results can be applied to improve the abdominal injury assessment in both anthropomorphic test devices and in computer models of the human body used in vehicle safety research.